Pathology Section, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Clinical Biostatistics Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Br J Haematol. 2022 Dec;199(5):696-706. doi: 10.1111/bjh.18404. Epub 2022 Aug 16.
Currently, there is no convincing evidence that the grade of follicular lymphoma (FL) impacts patient outcome. We correlated grades in 33 925 patients with nodal FL during 1992-2018 in the SEER database with disease-specific survival (DSS) and overall survival (OS). Patients with FL grade 3 had lower DSS and OS as compared to FL grades 1-2. During 1992-2005, the 10-year DSS for patients with FL grades 3 and grades 1-2 were 68.6%, and 71.4%, respectively, and in 2006-2018, they were 77.7% and 82.6%, respectively. The 10-year OS estimates in 1992-2005 were 49.9% and 54.2% for grade 3 and grades 1-2 respectively, and in 2006-2018, they were 59.1% and 63.5% for grade 3 and grades 1-2, respectively. After adjustment for stage and age, the hazard ratios for death due to FL and death from any cause for patients with FL grade 3 during 1992-2005 were 1.09 (1.02-1.16) and 1.07 (1.02-1.12), respectively, compared to FL grades 1-2; and during 2006-2018, the hazard ratios for death due to FL and death from any cause for patients with FL grade 3 were 1.34 (1.22-1.45) and 1.16 (1.10-1.23), respectively compared to FL grades 1-2. The grade of FL is an important determinant of disease biology.
目前，尚无令人信服的证据表明滤泡性淋巴瘤（FL）的分级会影响患者的预后。我们将 1992 年至 2018 年间 SEER 数据库中 33925 例结内滤泡性淋巴瘤患者的分级与疾病特异性生存率（DSS）和总生存率（OS）相关联。FL 3 级患者的 DSS 和 OS 低于 FL 1-2 级。1992 年至 2005 年，FL 3 级和 1-2 级患者的 10 年 DSS 分别为 68.6%和 71.4%，而在 2006 年至 2018 年，它们分别为 77.7%和 82.6%。1992 年至 2005 年，FL 3 级和 1-2 级患者的 10 年 OS 估计值分别为 49.9%和 54.2%，而在 2006 年至 2018 年，它们分别为 59.1%和 63.5%。在调整了分期和年龄后，1992 年至 2005 年 FL 3 级患者因 FL 死亡和因任何原因死亡的风险比分别为 1.09（1.02-1.16）和 1.07（1.02-1.12），而与 FL 1-2 级相比；而在 2006 年至 2018 年，FL 3 级患者因 FL 死亡和因任何原因死亡的风险比分别为 1.34（1.22-1.45）和 1.16（1.10-1.23）。FL 的分级是疾病生物学的一个重要决定因素。
