Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-ku, Seoul, 137-701, Korea.
Sci Rep. 2022 Aug 16;12(1):13866. doi: 10.1038/s41598-022-17868-8.
We evaluated the intereye structure-function relationship in glaucoma patients using photopic negative response in electroretinogram analysis. Patients with confirmed glaucoma (36 eyes, 36 patients) or suspected glaucoma (19 eyes, 19 patients) were included in this study. Electroretinogram (RETI-scan) was performed with red stimulus on blue background. Intereye comparison for 55 patients was performed between better eyes and worse eyes, which were divided based on average retinal nerve fiber layer (RNFL) thickness measured using spectral-domain optical coherence tomography. In the intereye analysis, PhNR amplitude was lower in worse eyes than in better eyes (P < 0.001). The intereye difference in PhNR amplitude was significantly correlated with intereye difference in average RNFL, as well as average or minimum ganglion cell-inner plexiform layer (GCIPL) thickness (P = 0.006, 0.044, 0.001). In patients with mean deviation ≥ - 6 dB of worse eyes, the intereye difference in PhNR amplitude was significantly associated with intereye difference in average RNFL thickness or minimum GCIPL thickness (P = 0.037, 0.007), but significant correlation was not found between mean sensitivity of visual field tests and structural parameters. In conclusion, PhNR performed well with regard to intereye structure-function association in glaucoma patients, especially at the early stage.
我们使用视网膜电图分析中的明视负向光反应评估青光眼患者的眼间结构-功能关系。本研究纳入了确诊青光眼（36 只眼，36 例患者）或疑似青光眼（19 只眼，19 例患者）患者。视网膜电图（RETI-scan）采用红色刺激在蓝色背景下进行。对 55 例患者的 55 对眼进行了更好眼和更差眼之间的眼间比较，这些眼是根据谱域光学相干断层扫描测量的平均视网膜神经纤维层（RNFL）厚度来划分的。在眼间分析中，更差眼的 PhNR 振幅低于更好眼（P<0.001）。PhNR 振幅的眼间差异与平均 RNFL 的眼间差异以及平均或最小节细胞内丛状层（GCIPL）厚度的眼间差异显著相关（P=0.006、0.044、0.001）。在更差眼的平均偏差≥-6 dB 的患者中，PhNR 振幅的眼间差异与平均 RNFL 厚度或最小 GCIPL 厚度的眼间差异显著相关（P=0.037、0.007），但视野测试的平均敏感度与结构参数之间无显著相关性。总之，PhNR 在青光眼患者的眼间结构-功能关系中表现良好，尤其是在早期阶段。
