Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Turku Institute of Advanced Studies, University of Turku, Turku, Finland.
Mol Psychiatry. 2022 Nov;27(11):4419-4431. doi: 10.1038/s41380-022-01710-8. Epub 2022 Aug 16.
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
了解记忆过程的基因组基础可能有助于对抗神经退行性疾病。因此，我们研究了无痴呆或中风的成年人中常见遗传变异与言语短期记忆和言语学习的关联（N=53637）。我们在 CDH18 的内含子区域以及 13q21 和 3p21.1 中发现了新的基因座，并且在 APOE/APOC1/TOMM40 区域发现了预期的信号。这些结果在独立样本中得到了复制。功能和生物信息学分析支持了其中许多基因座，并进一步暗示了 POC1 的作用。我们表明，言语学习的多基因评分与工作记忆任务期间右顶枕叶区域的大脑激活有关。最后，我们展示了这些记忆特征与几个神经认知和健康结果的遗传相关性。我们的研究结果表明，几个基因组座在言语记忆过程中起作用。
