在烧伤重症监护病房暴发期间，对头孢地尔耐药鲍曼不动杆菌的进化和传播。
Evolution and Transmission of Cefiderocol-Resistant Acinetobacter baumannii During an Outbreak in the Burn Intensive Care Unit.
机构信息
Department of Pharmacy, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Clin Infect Dis. 2023 Feb 8;76(3):e1261-e1265. doi: 10.1093/cid/ciac647.
Abstract
We report on 11 critically ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and interpatient transmission of cefiderocol-resistant A. baumannii. Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.
摘要
我们报告了 11 例重症烧伤患者使用头孢地尔治疗碳青霉烯类耐药鲍曼不动杆菌感染的情况。临床治愈率为 36%，但治疗中出现了耐药性和耐头孢地尔的鲍曼不动杆菌在患者间的传播。耐药分离株携带的 pirA 和 piuA 基因被破坏，而敏感分离株则没有被破坏。
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