Department of Psychology, UiT, The Artic University of Norway, Tromsø, Norway.
Department of Neurology, University Hospital of North Norway, Tromsø, Norway.
Laterality. 2022 Nov;27(6):581-604. doi: 10.1080/1357650X.2022.2111437. Epub 2022 Aug 16.
Research in Parkinson's or Alzheimer's disease suggests that hand function is affected by neurodegenerative diseases. However, little is known about the relationship between hand function and mild cognitive impairment (MCI). Therefore, we conducted a kinematic analysis of unimanual hand movements in MCI patients to answer whether manual asymmetries and manual dexterity are affected or preserved in this condition. Forty-one MCI patients and fifty healthy controls were tested with the Purdue Pegboard test. All participants were right-handed. Kinematic analyses (by hand) were calculated for path length, angle, and linear and angular velocities during reaching, grasping, transport and inserting. Group differences were tested by with factorial MANOVAs and laterality indexes (LI) were assessed. Groups were compared on "Right-Left" hand correlations to identify kinematics that best single-out patients. Kinematics from grasping and inserting were significantly more deteriorated in the MCI group, while outcomes for reaching and transport denoted superior performance. LIs data showed symmetry of movements in the MCI group, during reaching and transport. Comparisons of "Right-Left" hand correlations revealed that kinematics in reaching and transport were more symmetrical in patients. This study showed a deterioration of fine manual dexterity, an enhancement in gross dexterity of upper-limbs, and symmetrical movements in MCI patients.
帕金森病或阿尔茨海默病的研究表明，手部功能受神经退行性疾病的影响。然而，对于手部功能与轻度认知障碍（MCI）之间的关系知之甚少。因此，我们对 MCI 患者的单手手部运动进行了运动学分析，以回答在这种情况下手部的不对称性和灵巧性是否受到影响或保留。41 名 MCI 患者和 50 名健康对照者接受了 Purdue 钉板测试。所有参与者均为右利手。在伸手、抓握、运输和插入过程中，通过手部计算路径长度、角度以及线性和角速度的运动学分析。通过因子 MANOVAs 测试组间差异，并评估偏侧指数（LI）。比较组间“右手-左手”相关性，以确定最能区分患者的运动学。MCI 组在抓握和插入过程中的运动学明显恶化，而在伸手和运输过程中的结果表现出较好的性能。LI 数据显示 MCI 组在伸手和运输过程中运动具有对称性。“右手-左手”相关性的比较表明，患者在伸手和运输过程中的运动学更对称。这项研究显示 MCI 患者的精细手动灵巧性下降，上肢粗大灵巧性增强，运动具有对称性。
