Zhou Qian, Yu Ruixing, Xia Deju, Liu Jingwei, Xu Wenqi, Yin Yueping
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.
Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Indian J Microbiol. 2022 Sep;62(3):428-433. doi: 10.1007/s12088-022-01013-0. Epub 2022 Apr 21.
(gonococci) is the pathogen of gonorrhea. At present, there is no robust statistical analysis targeting the detection accuracy for of loop-mediated isothermal amplification (LAMP). We performed a full search of five databases for studies using the LAMP method to detect in this study. Nine datasets derived from eight studies satisfying the inclusion requirement were collected for this study. The pooled sensitivity rate and specificity were calculated as 98.53 and 99.49%. The pooled positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) were 66.0, 0.04 and 1863.8. After plotting the summary receiver operating characteristic (sROC), the area under the curve (AUC) and Q* index was calculated as 0.99 and 0.9774. Subgroup analyses based on the type of samples, location, and gold standard did not find sources of significant heterogeneity. In conclusion, the LAMP method could be an effective and convenient method with high accuracy for the clinical detection of . Moreover, the confirmation of this finding needs more high-quality studies with regional data and large samples.
（淋病奈瑟菌）是淋病的病原体。目前，针对环介导等温扩增（LAMP）检测（淋病奈瑟菌）的准确性尚无有力的统计分析。在本研究中，我们全面检索了五个数据库以查找使用LAMP方法检测（淋病奈瑟菌）的研究。本研究收集了来自八项满足纳入要求的研究的九个数据集。合并敏感度和特异度分别计算为98.53%和99.49%。合并阳性似然比（PLR）、阴性似然比（NLR）和诊断比值比（DOR）分别为66.0、0.04和1863.8。绘制汇总受试者工作特征（sROC）曲线后，曲线下面积（AUC）和Q*指数分别计算为0.99和0.9774。基于样本类型、地点和金标准的亚组分析未发现显著异质性来源。总之，LAMP方法可能是一种用于（淋病奈瑟菌）临床检测的有效、便捷且准确性高的方法。此外，这一发现的确认需要更多具有区域数据和大样本量的高质量研究。
