腹腔注射多巴胺对艾氏腹水癌荷瘤小鼠的抗肿瘤作用。
Antitumor effect of i.p. dopamine in mice bearing Ehrlich ascites carcinoma.
作者信息
Dasgupta P S, Lahiri T
出版信息
J Cancer Res Clin Oncol. 1987;113(4):363-8. doi: 10.1007/BF00397720.
Abstract
The cancer chemotherapeutic efficacy of dopamine (DA) was evaluated in female strain A mice bearing transplantable Ehrlich ascites carcinoma. The results demonstrated significant inhibition of tumor growth with appreciable increase in the host survival time following DA treatment. Diminished activity of the growth-related respiratory enzyme succinate dehydrogenase along with stimulated activity of the lysosomal enzyme, beta-glucuronidase in DA-treated tumor cells indicated inhibition of tumor growth as well as active lysis of the tumor cells. The direct effect of this compound on tumor proliferation was demonstrated by marked inhibition of DNA synthesis. RNA synthesis was only marginally inhibited.
摘要
在携带可移植艾氏腹水癌的雌性A系小鼠中评估了多巴胺（DA）的癌症化疗疗效。结果表明，多巴胺治疗后肿瘤生长受到显著抑制，宿主存活时间明显延长。多巴胺处理的肿瘤细胞中，与生长相关的呼吸酶琥珀酸脱氢酶活性降低，同时溶酶体酶β-葡萄糖醛酸酶活性受到刺激，表明肿瘤生长受到抑制，肿瘤细胞发生主动裂解。DNA合成受到显著抑制，证明了该化合物对肿瘤增殖的直接作用。RNA合成仅受到轻微抑制。
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