Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(6):828-835. doi: 10.3724/abbs.2022061.
DNA damage repair and innate immunity are two conserved mechanisms that both function in cellular stress responses. Recently, an increasing amount of evidence has uncovered the close relationship between these two ancient biological processes. Here, we review the classical function of factors involved in DNA repair, and especially double-strand break repair, in innate immunity; more importantly, we discuss the novel roles of DNA repair factors in regulating innate immunity and . In addition, we also review the roles of DNA repair, innate immunity and their crosstalk in human diseases, which suggest that these two pathways may be compelling targets for disease prevention and treatment.
DNA 损伤修复和先天免疫是两种保守的机制，它们都在细胞应激反应中发挥作用。最近，越来越多的证据揭示了这两个古老的生物过程之间的密切关系。在这里，我们回顾了参与 DNA 修复的因素，特别是双链断裂修复，在先天免疫中的经典功能；更重要的是，我们讨论了 DNA 修复因子在调节先天免疫中的新作用。此外，我们还回顾了 DNA 修复、先天免疫及其相互作用在人类疾病中的作用，这表明这两个途径可能是疾病预防和治疗的有吸引力的靶点。
