生活简单 7 项指标与脑小血管病的关联。
Associations of Life's Simple 7 With Cerebral Small Vessel Disease.
机构信息
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (D.L., Y.Y., D.Y., J.J., H.Y., X.M., H.L., Yongjun Wang, Y.P., Yilong Wang).
China National Clinical Research Center for Neurological Diseases, Beijing (D.L., Y.Y., D.Y., J.J., H.Y., X.M., H.L., Yongjun Wang, Y.P., Yilong Wang).
出版信息
Stroke. 2022 Sep;53(9):2859-2867. doi: 10.1161/STROKEAHA.122.038838. Epub 2022 Aug 17.
BACKGROUND
The purpose of this study is to examine the associations of Life's Simple 7 (LS7) with risks of cerebral small vessel disease (CSVD) and its magnetic resonance imaging markers.
METHODS
Community-dwelling residents in Lishui city in China from the cross-sectional survey of the PRECISE study (Polyvascular Evaluation for Cognitive Impairment and Vascular Events) were included in this study from 2017 to 2019. LS7 was analyzed as the total score, medical score (derived from the 3 metrics based on medical history and testing), and behavioral score (based on 4 metrics based on behaviors), and categorized as poor, intermediate, or ideal. A CSVD score or a modified CSVD score was derived from 4 magnetic resonance imaging markers (lacunes, microbleeds, perivascular spaces, and white matter hyperintensity) at baseline. Binary logistic regression or ordinal logistic regression model was used to estimate the relationship of LS7 scores with CSVD and magnetic resonance imaging markers.
RESULTS
A total of 3061 participants were included in this study. Compared with poor total LS7 score, ideal LS7 total score was associated with reduced adjusted odds of higher CSVD score (common odds ratio [cOR], 0.73 [95% CI, 0.58-0.90]) and higher modified CSVD score (cOR, 0.78 [95% CI, 0.64-0.95]). Compared with poor LS7 medical score, ideal LS7 medical score was associated with reduced adjusted odds of higher CSVD score (cOR, 0.65 [95% CI, 0.53-0.80]) and higher modified CSVD score (cOR, 0.67 [95% CI, 0.56-0.81]). Higher total LS7 score and LS7 medical score were associated with a lower risk of white matter hyperintensities and lacunes. Higher LS7 behavioral score was associated with lower risk of lacunes.
CONCLUSIONS
Ideal LS7 score, indicating excellent cardiovascular health, was associated with lower total CSVD burden. Optimizing the risk factors captured by LS7 may reduce the progression of CSVD.
背景
本研究旨在探讨 Life's Simple 7（LS7）与脑小血管疾病（CSVD）及其磁共振成像标志物风险的相关性。
方法
本研究纳入了 2017 年至 2019 年来自中国丽水市 PRECISE 研究（认知障碍和血管事件的多血管评估）的社区居民。LS7 被分析为总分、医疗评分（源自基于病史和检测的 3 项指标）和行为评分（基于基于行为的 4 项指标），并分为差、中或理想。CSVD 评分或改良 CSVD 评分是根据基线时的 4 个磁共振成像标志物（腔隙、微出血、血管周围间隙和脑白质高信号）得出的。采用二元逻辑回归或有序逻辑回归模型估计 LS7 评分与 CSVD 和磁共振成像标志物的关系。
结果
共纳入 3061 名参与者。与较差的总 LS7 评分相比，理想的 LS7 总分与较低的调整后高 CSVD 评分（常见比值比 [cOR]，0.73 [95%CI，0.58-0.90]）和较高的改良 CSVD 评分（cOR，0.78 [95%CI，0.64-0.95]）的可能性降低相关。与较差的 LS7 医疗评分相比，理想的 LS7 医疗评分与较低的调整后高 CSVD 评分（cOR，0.65 [95%CI，0.53-0.80]）和较高的改良 CSVD 评分（cOR，0.67 [95%CI，0.56-0.81]）的可能性降低相关。较高的总 LS7 评分和 LS7 医疗评分与较低的脑白质高信号和腔隙的风险相关。较高的 LS7 行为评分与腔隙的风险降低相关。
结论
理想的 LS7 评分表明心血管健康状况良好，与总 CSVD 负担较低相关。优化 LS7 所包含的风险因素可能会降低 CSVD 的进展。
Zotero 插件