Key Laboratory of Tropical Medicinal Resources Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China.
Nat Prod Res. 2023 Jun;37(12):1961-1968. doi: 10.1080/14786419.2022.2112577. Epub 2022 Aug 17.
The phytochemical study on the stems and leaves of L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A (), together with five known analogues (-). The chemical structure of was elucidated by comprehensive spectral analyses. The known compounds - were identified by comparing their spectral data with those reported in the literature, which were isolated from for the first time. In addition, the anti-inflammatory and anti-HIV activities of compounds - were evaluated . Compounds - displayed significant inhibitory activities on NO (nitric oxide) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells with IC values ranging from 0.98 ± 0.07 to 6.32 ± 0.11 μM, which was comparable to hydrocortisone. Meanwhile, compounds - showed remarkable anti-HIV-1 reverse transcriptase (RT) effects with the EC values ranging from 0.16 to 6.29 μM.
对 茎叶的植物化学研究导致分离得到一种新的天然存在的倍半萜类化合物，morincitrinoid A ()，以及五个已知类似物 (-)。通过综合光谱分析阐明了的化学结构。通过将已知化合物的光谱数据与文献中报道的那些进行比较，鉴定了 -，它们是首次从 中分离得到的。此外，还评估了化合物 - 的抗炎和抗 HIV 活性。化合物 - 对脂多糖诱导的小鼠巨噬细胞 RAW 264.7 细胞中 NO（一氧化氮）产生具有显著的抑制活性，IC 值范围为 0.98±0.07 至 6.32±0.11 μM，与氢化可的松相当。同时，化合物 - 对 HIV-1 逆转录酶 (RT) 表现出显著的抑制作用，EC 值范围为 0.16 至 6.29 μM。
