Jin Yue, Tian Shengjun, Xue Jian
Department of Molecular Diagnosis, Northern Jiangsu People's Hospital, Yangzhou, China.
Department of Neurology, Yantaishan Hospital, Yantai, China.
Nat Prod Res. 2025 Jul;39(14):4193-4197. doi: 10.1080/14786419.2024.2356651. Epub 2024 Jun 2.
Endophytic fungi can produce attractive secondary metabolites with various biological activities that have contributed significantly to pharmacotherapy. In this study, three bisabolane-type sesquiterpenoids, including a new one, namely, inonotic acid C (), together with previously reported compounds ()-(+)-11-dehydrosydonic acid () and sydonic acid (), were isolated from a marine algal-derived endophytic fungus MZY-202312-521. Their structures were determined by means of extensive spectroscopic analyses. The absolute configurations of inonotic acid C () were established by single-crystal X-ray diffraction method. cytotoxic experiments on human A549, MCF-7, HeLa, and HepG2 carcinoma cell lines were carried out. The new compound inonotic acid C () was found to possess strong inhibitory activity against the MCF-7 cell line, with an IC value of 7.7 μM.
内生真菌能够产生具有多种生物活性的、引人注目的次生代谢产物，这些产物对药物治疗有显著贡献。在本研究中，从一株海洋藻类来源的内生真菌MZY - 202312 - 521中分离出三种没药烷型倍半萜类化合物，其中包括一种新化合物，即异诺替酸C（），以及先前报道的化合物（）-（+）-11 - 脱氢西德onic酸（）和西德onic酸（）。通过广泛的光谱分析确定了它们的结构。异诺替酸C（）的绝对构型通过单晶X射线衍射法确定。对人A549、MCF - 7、HeLa和HepG2癌细胞系进行了细胞毒性实验。发现新化合物异诺替酸C（）对MCF - 7细胞系具有较强的抑制活性，IC值为7.7 μM。
