TRIM59 在免疫和免疫相关疾病中的作用。
The role of TRIM59 in immunity and immune-related diseases.
机构信息
Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, China.
Divison of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA.
出版信息
Int Rev Immunol. 2024;43(1):33-40. doi: 10.1080/08830185.2022.2102618. Epub 2022 Aug 17.
TRIM59 is a member of the tripartite motif containing (TRIM) protein family. It functions as an E3 ubiquitin ligase through its RING domain and is expressed by multiple types of cells. Physiogically, TRIM59 is involved in development, immune response, and the invasion and metastasis of tumors. In this review, we first describe the structure, expression, and subcellular location of TRIM59. Then, we summarize emerging evidence for TRIM59 in immunological diseases including infection, vascular diseases, autoimmunity, and tumor immunity. Additionally, we discuss important molecular signaling pathways that mediate TRIM59 activity. Altogether, the accumulating evidence suggests that manipulating TRIM59 levels and activity may open an avenue for innovative therapies for immune diseases and tumors.
TRIM59 是包含三部分基序的蛋白家族（TRIM）的成员。它通过其 RING 结构域作为 E3 泛素连接酶发挥作用，并由多种类型的细胞表达。从生理上讲，TRIM59 参与发育、免疫反应以及肿瘤的侵袭和转移。在这篇综述中，我们首先描述了 TRIM59 的结构、表达和亚细胞定位。然后，我们总结了 TRIM59 在包括感染、血管疾病、自身免疫和肿瘤免疫在内的免疫性疾病中的新出现的证据。此外，我们还讨论了介导 TRIM59 活性的重要分子信号通路。总的来说，越来越多的证据表明，操纵 TRIM59 的水平和活性可能为免疫性疾病和肿瘤的创新治疗开辟途径。
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