Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated-Materials, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, China.
College of Biological Science and Engineering, 350108, Fuzhou, Fujian, China.
Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202210019. doi: 10.1002/anie.202210019. Epub 2022 Aug 31.
Herein, a giant Sb-rich polyoxometalate (POM) {Sb Tb W } is reported, which contains the largest number of Sb atoms in a POM so far. The Sb-rich POM has many interesting structural features and is a rare example of a soluble and water-stable giant POM. Biomedical studies indicate that the Sb-rich POM exhibits broad-spectrum antitumor activity against various cancer cell lines by reactivating the P53-dependent apoptotic processes and disrupting the mitochondrial membrane. In addition, this Sb-rich POM was capable of suppressing the growth and metastasis of a breast cancer in vivo. This work demonstrates that Sb-rich POMs are promising candidates for the development of new anticancer drugs.
本文报道了一种富 Sb 的多金属氧酸盐（POM）{Sb Tb W }，其中包含迄今为止 POM 中最多数量的 Sb 原子。这种富 Sb 的 POM 具有许多有趣的结构特征，是一种罕见的可溶性和水稳定的巨型 POM 实例。生物医学研究表明，富 Sb 的 POM 通过重新激活 P53 依赖性凋亡过程和破坏线粒体膜，对各种癌细胞系表现出广谱的抗肿瘤活性。此外，这种富 Sb 的 POM 能够抑制体内乳腺癌的生长和转移。这项工作表明，富 Sb 的 POM 是开发新型抗癌药物的有前途的候选物。
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