Department of Radiation Oncology, Division of Free Radical and Radiation Biology, The University of Iowa, Iowa City, IA 52242-1181, USA.
Spheres4Life B.V., 7521 Enschede, The Netherlands.
Int J Mol Sci. 2022 Jul 27;23(15):8263. doi: 10.3390/ijms23158263.
Polyoxometalate nanoparticles (POMs) are a class of compounds made up of multiple transition metals linked together using oxygen atoms. POMs commonly include group 6 transition metals, with two of the most common forms using molybdenum and tungsten. POMs are suggested to exhibit antimicrobial effects. In this study, we developed two POM preparations to study anti-cancer activity. We found that Mo-POM (NH)MoO) and W-POM (HPWO) have anti-cancer effects on glioblastoma cells. Both POMs induced morphological changes marked by membrane swelling and the presence of multinucleated cells that may indicate apoptosis induction along with impaired cell division. We also observed significant increases in lipid oxidation events, suggesting that POMs are redox-active and can catalyze detrimental oxidation events in glioblastoma cells. Here, we present preliminary indications that molybdenum polyoxometalate nanoparticles may act like ferrous iron to catalyze the oxidation of phospholipids. These preliminary results suggest that Mo-POMs (NH)MoO) and W-POMs (HPWO) may warrant further investigation into their utility as adjunct cancer therapies.
多金属氧酸盐纳米粒子（POMs）是一类由多个过渡金属通过氧原子连接而成的化合物。POMs 通常包含第 6 族过渡金属，其中最常见的两种形式是使用钼和钨。有研究表明 POMs 具有抗菌作用。在本研究中，我们开发了两种 POM 制剂来研究其抗癌活性。我们发现 Mo-POM（(NH)MoO）和 W-POM（HPWO）对神经胶质瘤细胞具有抗癌作用。这两种 POM 都诱导了形态变化，表现为细胞膜肿胀和多核细胞的出现，这可能表明诱导了细胞凋亡以及细胞分裂受损。我们还观察到脂质氧化事件显著增加，这表明 POMs 是具有氧化还原活性的，能够在神经胶质瘤细胞中催化有害的氧化反应。在这里，我们初步表明钼多金属氧酸盐纳米粒子可能像二价铁一样，催化磷脂的氧化。这些初步结果表明，Mo-POM（(NH)MoO）和 W-POM（HPWO）可能值得进一步研究，作为辅助癌症治疗的方法。
