Slais K, Nielen M W, Brinkman U A, Frei R W
J Chromatogr. 1987 Apr 22;393(1):57-68. doi: 10.1016/s0021-9673(01)94204-9.
Amphetamine-type drugs with a wide polarity range have been screened in both human and horse urine using on-line pre-concentration on pre-columns packed with hydrophobic and cation-exchange sorbents in series and gradient microbore high-performance liquid chromatography. The underivatized amphetamines were identified by UV detection at 210 nm. The method has potential for the automated liquid chromatographic screening of amphetamines in urine, e.g., for doping control.
使用串联填充有疏水和阳离子交换吸附剂的预柱进行在线预浓缩，并结合梯度微径高效液相色谱法，已对极性范围广泛的苯丙胺类药物在人尿和马尿中进行了筛查。通过在210nm处的紫外检测来鉴定未衍生化的苯丙胺类药物。该方法具有用于尿液中苯丙胺类药物自动液相色谱筛查的潜力，例如用于兴奋剂检测。
