Martínez A, Heinrich J J, Domené H, Escobar M E, Jasper H, Montuori E, Bergadá G
J Clin Endocrinol Metab. 1987 Aug;65(2):253-7. doi: 10.1210/jcem-65-2-253.
The growth response to 100 ng/kg BW X day ethinyl estradiol (2-4 micrograms/day) given for 18 months was studied in a group of nine patients with Turner's syndrome, aged 8.6-13.3 yr. All patients were prepubertal and had elevated gonadotropin levels. Growth velocity increased from 3.09 +/- 1.05 (+/-SD) to 7.09 +/- 1.47 cm/yr in the first 6 months, 6.08 +/- 1.78 cm/yr in the second 6 months, and 4.03 +/- 1.65 cm/yr in the third 6 months. Bone age increased a mean of 0.82 +/- 0.34, 0.89 +/- 0.79, and 0.74 +/- 0.59 yr, respectively, in the three 6-month periods. Predicted height prognosis did not change after any period. All patients had pubertal changes, limited in most to slight breast development. Mean diurnal spontaneous GH secretion did not change during treatment. Plasma somatomedin-C levels were low before treatment, and ethinyl estradiol did not significantly increase somatomedin-C values. Our data confirm the ability of a low dose of ethinyl estradiol to increase growth velocity in girls with Turner's syndrome, although the effect diminished with time, and the excess bone age advancement precluded improvement of predicted height.
对一组9名年龄在8.6至13.3岁的特纳综合征患者，研究了给予100 ng/kg体重/天乙炔雌二醇（2 - 4微克/天）持续18个月后的生长反应。所有患者均为青春期前，促性腺激素水平升高。生长速度在前6个月从3.09±1.05（±标准差）厘米/年增加到7.09±1.47厘米/年，在第二个6个月为6.08±1.78厘米/年，在第三个6个月为4.03±1.65厘米/年。在三个6个月期间，骨龄分别平均增加0.82±0.34、0.89±0.79和0.74±0.59岁。任何时期后预测身高预后均未改变。所有患者均有青春期变化，大多数仅限于轻微乳房发育。治疗期间平均日自发性生长激素分泌未改变。治疗前血浆生长调节素-C水平较低，乙炔雌二醇未显著增加生长调节素-C值。我们的数据证实了低剂量乙炔雌二醇能增加特纳综合征女孩的生长速度，尽管效果随时间减弱，且骨龄提前过多妨碍了预测身高的改善。
