ten Berge R J, Schellekens P T, Budding-Koppenol A, Dooren L J, Vossen J M
J Clin Immunol. 1987 May;7(3):198-202. doi: 10.1007/BF00915724.
Natural killer-cell activity for K562 target cells was measured in 13 patients with severe combined immunodeficiency before bone marrow transplantation. Both unseparated peripheral blood mononuclear cells and sorted cell subsets (B73.1 positive, B73.1 negative, OKT3 positive, OKT3 negative) were tested. Heterogeneity of natural killer-cell activity was observed, the level of which did not correlate with the usual subdivision of severe combined immunodeficiency, as defined by a scientific group on immunodeficiency for the WHO. In those patients in whom natural killer-cell activity was observed in unseparated cells, testing of this function in sorted cell subsets revealed some unexpected findings. In three of four patients, B73.1-negative cells showed remarkable natural killer-cell activity. In addition, in one of these patients, no activity was observed in the B73.1-positive cells.
在13例严重联合免疫缺陷患者进行骨髓移植前，检测了其针对K562靶细胞的自然杀伤细胞活性。对未分离的外周血单个核细胞以及分选的细胞亚群（B73.1阳性、B73.1阴性、OKT3阳性、OKT3阴性）均进行了检测。观察到自然杀伤细胞活性存在异质性，其水平与世界卫生组织免疫缺陷科学小组所定义的严重联合免疫缺陷的常见分类无关。在未分离细胞中观察到自然杀伤细胞活性的那些患者中，对分选细胞亚群的该功能检测发现了一些意外结果。在4例患者中的3例，B73.1阴性细胞显示出显著的自然杀伤细胞活性。此外，在其中1例患者中，B73.1阳性细胞未观察到活性。
