晚期糖基化终产物：它们会损害糖尿病患者的骨骼健康吗？

Advanced Glycation End Products: Do They Impair Bone Health in Diabetes?

机构信息

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece.

Department of Health Promotion Sciences, Maternal and Infantile Care, Internal Medicine and Medical Specialties (Promise), School of Medicine, University of Palermo, Italy.

出版信息

Exp Clin Endocrinol Diabetes. 2022 Oct;130(10):636-637. doi: 10.1055/a-1903-1752. Epub 2022 Aug 17.

DOI:10.1055/a-1903-1752

PMID:35977693

Abstract

In diabetes mellitus (DM), there is increased formation and accumulation of advanced glycation end products (AGEs), which represent a heterogeneous class of molecules produced by non-enzymatic glycation of various molecules during long-term hyperglycaemia. Several studies have examined the role of AGEs in DM complications. Accumulating evidence suggests that AGEs affect bone metabolism. New knowledge indicates that they may play a role in bone disease among DM subjects. More data are now needed to clarify their role and to explore new AGEs-based therapeutic options for optimal bone health in DM.

摘要

在糖尿病（DM）中，存在高级糖基化终产物（AGEs）的形成和积累增加，AGEs 是由长期高血糖导致各种分子的非酶糖基化产生的一类异质分子。有几项研究探讨了 AGEs 在 DM 并发症中的作用。越来越多的证据表明，AGEs 影响骨代谢。新知识表明，它们可能在 DM 患者的骨骼疾病中发挥作用。现在需要更多的数据来阐明它们的作用，并探索新的基于 AGEs 的治疗选择，以实现 DM 患者的骨骼健康。