晚期糖基化终产物及其对 2 型糖尿病血管并发症的影响。
Advanced Glycation End Products and Their Effect on Vascular Complications in Type 2 Diabetes Mellitus.
机构信息
Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03391, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea.
出版信息
Nutrients. 2022 Jul 27;14(15):3086. doi: 10.3390/nu14153086.
Abstract
Diabetes is well established as a chronic disease with a high health burden due to mortality or morbidity from the final outcomes of vascular complications. An increased duration of hyperglycemia is associated with abnormal metabolism. Advanced glycation end products (AGEs) are nonenzymatic glycated forms of free amino acids that lead to abnormal crosslinking of extra-cellular and intracellular proteins by disrupting the normal structure. Furthermore, the interaction of AGEs and their receptors induces several pathways by promoting oxidative stress and inflammation. In this review, we discuss the role of AGEs in diabetic vascular complications, especially type 2 DM, based on recent clinical studies.
摘要
糖尿病是一种慢性疾病，由于血管并发症的最终结果导致的死亡率或发病率，其健康负担很高。高血糖持续时间的延长与代谢异常有关。晚期糖基化终产物（AGEs）是游离氨基酸的非酶糖化形式，通过破坏正常结构导致细胞外和细胞内蛋白质的异常交联。此外，AGEs 及其受体的相互作用通过促进氧化应激和炎症诱导了几种途径。在这篇综述中，我们根据最近的临床研究讨论了 AGEs 在糖尿病血管并发症中的作用，特别是 2 型糖尿病。
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