全面生育力生物银行计划的实施。
Implementation of a comprehensive fertility biobanking initiative.
机构信息
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Stanford University, Sunnyvale, California.
Department of Urology, Stanford University, Stanford, California.
出版信息
F S Sci. 2022 Aug;3(3):228-236. doi: 10.1016/j.xfss.2022.01.001. Epub 2022 Jan 13.
OBJECTIVE
To present the framework of Stanford Fertility and Reproductive Health's comprehensive reproductive biobanking initiatives and the results of the first year of recruitment.
DESIGN
Technical description article.
SETTING
Academic fertility center.
PATIENT(S): Fertility patients >18 years of age.
INTERVENTION(S): Enroll the patients interested in research in biobanking protocols.
MAIN OUTCOME MEASURE(S): Patient recruitment and sample inventory from September 2020 to September 2021.
RESULT(S): A total of 253 patients have enrolled in the Stanford Fertility and Reproductive Health biobanking initiatives since September 2020. The current inventory consists of 1,176 samples, including serums, plasmas, buffy coats, endometria, maternal deciduae, miscarriage chorionic villi, and human embryos (zygote, cleavage, and blastocyst stages).
CONCLUSION(S): This biobanking initiative addresses a critical, unmet need in reproductive health research to make it possible for patients to donate excess embryos and gametes and preserves, for future research, valuable somatic and reproductive tissues that would otherwise be discarded. We present the framework of this biobanking initiative in order to support future efforts of establishing similar biorepositories.
目的
介绍斯坦福生育与生殖健康综合生殖生物库计划的框架以及第一年招募的结果。
设计
技术描述文章。
地点
学术生育中心。
患者
年龄大于 18 岁的生育患者。
干预措施
招募有兴趣参与生物库方案研究的患者。
主要观察指标
2020 年 9 月至 2021 年 9 月的患者招募和样本库存情况。
结果
自 2020 年 9 月以来，共有 253 名患者参加了斯坦福生育与生殖健康生物库计划。目前的库存包括 1176 份样本，包括血清、血浆、白细胞层、子宫内膜、母体胎盘、流产绒毛膜和人类胚胎（受精卵、分裂期和囊胚期）。
结论
该生物库计划满足了生殖健康研究中一个关键的未满足需求，使患者能够捐献多余的胚胎和配子，并保存否则将被丢弃的有价值的体细胞和生殖组织，以备未来的研究使用。我们介绍了这个生物库计划的框架，以支持未来建立类似生物库的努力。
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