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A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD.

作者信息

Liu Shuo, Jia Zijing, Nie Jianhui, Liang Ziteng, Xie Jingshu, Wang Lei, Zhang Li, Wang Xiangxi, Wang Youchun, Huang Weijin

机构信息

Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, China.

CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

出版信息

Cell Discov. 2022 Aug 17;8(1):81. doi: 10.1038/s41421-022-00443-w.

DOI:10.1038/s41421-022-00443-w
PMID:35977939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9385086/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda1/9385989/b69fdcb6ac47/41421_2022_443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda1/9385989/b69fdcb6ac47/41421_2022_443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda1/9385989/b69fdcb6ac47/41421_2022_443_Fig1_HTML.jpg

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Protein Cell. 2024 Dec 2;15(12):930-937. doi: 10.1093/procel/pwae033.
2
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron.SARS-CoV-2 奥密克戎株感染性和免疫逃避的结构与功能特征。
Cell. 2022 Mar 3;185(5):860-871.e13. doi: 10.1016/j.cell.2022.01.019. Epub 2022 Jan 25.
3
Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants.
针对多种 SARS-CoV-2 变体的三价疫苗接种者的记忆 B 细胞库。
Nature. 2022 Mar;603(7903):919-925. doi: 10.1038/s41586-022-04466-x. Epub 2022 Jan 28.
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Regular and booster vaccination with inactivated vaccines enhance the neutralizing activity against Omicron variant both in the breakthrough infections and vaccinees.使用灭活疫苗进行常规和加强接种可增强突破性感染患者和接种疫苗者对奥密克戎变种的中和活性。
J Infect. 2022 Apr;84(4):579-613. doi: 10.1016/j.jinf.2022.01.004. Epub 2022 Jan 10.
5
Analysis of Immune Escape Variants from Antibody-Based Therapeutics against COVID-19: A Systematic Review.基于抗体的 COVID-19 治疗药物的免疫逃逸变异体分析:系统评价。
Int J Mol Sci. 2021 Dec 21;23(1):29. doi: 10.3390/ijms23010029.
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