Onyemelukwe G C, Esievo K A, Kwanashie C N, Kulkarni A G, Obinechie E N
J Comp Pathol. 1987 Mar;97(2):143-7. doi: 10.1016/0021-9975(87)90034-x.
Membrane-bound erythrocyte surface sialic acid concentrations in sickle-cell human patients (SS) and in control patients with sickle-cell trait (AS) and normal genes (AA) were assayed. The erythrocyte sialic acid concentration was significantly (P less than 0.001) higher in sickle-cell patients than in non-sicklers and although the concentration was higher in AS than AA individuals the difference was not significant (P greater than 0.05). The anaemic state of the SS patients was shown by a significantly (P less than 0.001) lower PCV than in non-sicklers. This finding is discussed in relation to membrane toughness and subsequent membrane loss leading to irreversible sickling of red cells in the deoxygenated state.
对镰状细胞病患者（SS）、携带镰状细胞性状的对照患者（AS）以及具有正常基因的患者（AA）的膜结合红细胞表面唾液酸浓度进行了测定。镰状细胞病患者的红细胞唾液酸浓度显著高于非镰状细胞病患者（P<0.001），尽管AS个体的浓度高于AA个体，但差异不显著（P>0.05）。SS患者的贫血状态表现为其血细胞比容显著低于非镰状细胞病患者（P<0.001）。结合膜韧性以及随后导致去氧状态下红细胞不可逆镰变的膜损失，对这一发现进行了讨论。
