Westerman M P, Diloy-Puray M, Streczyn M
Biochim Biophys Acta. 1979 Oct 19;557(1):149-55. doi: 10.1016/0005-2736(79)90097-x.
Cholesterol, phospholipid and sialic acid were measured in red cells from patients with sickle cell anemia to determine whether the cells had abnormal concentrations of these components and whether the amounts of these compounds differed in irreversibly sickled cells as compared to non-irreversibly sickled cells. Sickle cells had significantly higher levels of both lipids than similar populations of normal cells, however, comparisons to populations of young control cells showed that the differences were generally not significant. Sialic acid levels in sickle cells were not significantly different from normal cells. Irreversibly sickled cells had lower lipid and sialic acid concentrations than those not irreversibly sickled, but the differences were either not significant or did not occur when compared to young control cells. The studies show that the increased lipid concentrations in the membrane of sickle cells are not abnormal but are related to cell age and that the decrease in membrane components in irreversibly sickled cells is no greater than would be predicted for similarly aged populations of cells.
对镰状细胞贫血患者的红细胞进行胆固醇、磷脂和唾液酸检测，以确定这些细胞中这些成分的浓度是否异常，以及与非不可逆镰状细胞相比，不可逆镰状细胞中这些化合物的含量是否存在差异。镰状细胞的两种脂质水平均显著高于正常细胞群体，但与年轻对照细胞群体相比，差异通常不显著。镰状细胞中的唾液酸水平与正常细胞无显著差异。不可逆镰状细胞的脂质和唾液酸浓度低于非不可逆镰状细胞，但与年轻对照细胞相比，差异不显著或不存在。研究表明，镰状细胞膜中脂质浓度的增加并非异常，而是与细胞年龄有关，不可逆镰状细胞膜成分的减少并不比同龄细胞群体预期的更大。
