School of Pharmacy, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia.
Jimma University Laboratory of Drug Quality (JULaDQ), Jimma, Oromia, Ethiopia.
Biomed Res Int. 2022 Aug 8;2022:5791308. doi: 10.1155/2022/5791308. eCollection 2022.
Pharmaceutical excipients derived from natural sources like resins are nowadays meritoriously used in the formulation of drugs. Resins of natural origin have many advantages over chemically synthesized substances; they are safer, nontoxic, less expensive, biodegradable, and widely available. To our knowledge, resins from plants have been not sufficiently explored for application in pharmaceutical formulations. Thus, in the present study, a resin isolated from Engl was characterized for its potential use as a pharmaceutical excipient. . The resin was extracted from the oleo gum resin of Engl, which involved the removal of volatile oils, gum, and Boswellic acid contents. The dried resin powder was then characterized for its micromeritic properties, heavy metal contents, moisture content, moisture absorption power, pH, solubility, swelling property, and acute toxicity profile. Moreover, the crystal nature and the chemical functionality of the resin were evaluated by using X-ray diffraction and Fourier transform infrared spectrometry, respectively. . The yield of the neutral resin was 13.17%, and the powder was pale yellow and had irregular surfaces. The resin was freely soluble in organic solvents but almost insoluble in water. The moisture content of the dried extract was 2.5% while its moisture absorption capacity was 2.5%, 4%, and 5.47% at 40%, 60%, and 75% RH, respectively. Besides, the maximum swelling capacities of the resin observed were 40%, 37%, and 30% at 350C, 300C, and 250C, respectively. The bulk powder exhibited a 1.21 Hausner ratio, 36.497 angles of repose, and 17.03% Carr's index, indicating the fair flowability of the powder. Heavy metals such as zinc, chromium, and cobalt were detected at a low level while elements like copper, manganese, lead, and cadmium were absent. The X-ray diffraction study revealed that the crystallinity index of the powder was 42.7% with a crystal size of 994.5A. The resin could be safe in mice up to 3 g/kg of their body weight. In conclusion, the physicochemical properties of the resin powder investigated reveal its potential application as pharmaceutical additives in the formulation of modified release solid dosages forms like tablets and microcapsules.
天然来源的药用辅料如树脂，如今在药物制剂中得到了很好的应用。天然来源的树脂比化学合成物质具有许多优势；它们更安全、无毒、更便宜、可生物降解且广泛可用。据我们所知，植物来源的树脂尚未充分开发用于药物制剂。因此，在本研究中，从 Engl 中分离出一种树脂，对其作为药用辅料的潜力进行了表征。。树脂是从 Engl 的油胶树脂中提取的，其中涉及挥发性油、胶和 Boswellic 酸含量的去除。然后对干燥的树脂粉末的微粉特性、重金属含量、水分含量、吸湿能力、pH 值、溶解度、溶胀性能和急性毒性特征进行了表征。此外，还分别使用 X 射线衍射和傅里叶变换红外光谱法评估了树脂的晶体性质和化学官能团。。中性树脂的产率为 13.17%，粉末呈淡黄色，表面不规则。树脂在有机溶剂中完全溶解，但几乎不溶于水。干燥提取物的水分含量为 2.5%，而其在 40%、60%和 75%相对湿度下的吸湿能力分别为 2.5%、4%和 5.47%。此外，观察到树脂的最大溶胀率分别为 350C、300C 和 250C 时的 40%、37%和 30%。散装粉末的 Hausner 比为 1.21，休止角为 36.497，卡尔指数为 17.03%，表明粉末具有良好的流动性。锌、铬和钴等重金属的含量较低，而铜、锰、铅和镉等元素则不存在。X 射线衍射研究表明，粉末的结晶度指数为 42.7%，晶体尺寸为 994.5A。在 3 g/kg 体重的范围内，树脂在小鼠体内可能是安全的。总之，研究中考察的树脂粉末的物理化学性质表明，它有可能作为药用辅料应用于片剂和微胶囊等控释固体制剂的制剂中。
