Yan Shushan, Wang Shufeng, Wang Xinyi, Dai Wenqing, Chu Jinjin, Cheng Min, Guo Zhiliang, Xu Donghua
Department of Gastrointestinal and Anal Diseases Surgery of the Affiliated Hospital, Weifang Medical University, Weifang, China.
Medical Experimental Training Center, Weifang Medical University, Weifang, China.
Front Oncol. 2022 Aug 1;12:954329. doi: 10.3389/fonc.2022.954329. eCollection 2022.
Metabolic reprogramming plays a critical role in colorectal cancer (CRC). It contributes to CRC by shaping metabolic phenotypes and causing uncontrolled proliferation of CRC cells. Glucose metabolic reprogramming is common in carcinogenesis and cancer progression. Growing evidence has implicated the modifying effects of non-coding RNAs (ncRNAs) in glucose metabolic reprogramming and chemoresistance in CRC. In this review, we have summarized currently published studies investigating the role of ncRNAs in glucose metabolic alterations and chemoresistance in CRC. Elucidating the interplay between ncRNAs and glucose metabolic reprogramming provides insight into exploring novel biomarkers for the diagnosis and prognosis prediction of CRC.
代谢重编程在结直肠癌（CRC）中起着关键作用。它通过塑造代谢表型和导致CRC细胞的不受控制增殖来促进CRC。葡萄糖代谢重编程在致癌作用和癌症进展中很常见。越来越多的证据表明非编码RNA（ncRNAs）在CRC的葡萄糖代谢重编程和化疗耐药性中具有调节作用。在这篇综述中，我们总结了目前已发表的研究，这些研究调查了ncRNAs在CRC的葡萄糖代谢改变和化疗耐药性中的作用。阐明ncRNAs与葡萄糖代谢重编程之间的相互作用，为探索用于CRC诊断和预后预测的新型生物标志物提供了思路。
