Department of Medicine, University of Connecticut, Farmington, CT 06030, United States.
Department of Medicine, Albany Medical College, Albany, NY 12208, United States.
World J Gastroenterol. 2022 Jun 28;28(24):2667-2679. doi: 10.3748/wjg.v28.i24.2667.
Introduction of proton pump inhibitor (PPI) therapy into clinical practice has revolutionized treatment approach to acid-related diseases. With its clinical success came a widespread use of PPI therapy. Subsequently, several studies found that PPIs were oftentimes overprescribed in primary care and emergency setting, likely attributed to seemingly low side-effect profile and physicians having low threshold to initiate therapy. However, now there is a growing concern over PPI side-effect profile among both patients and providers. We would like to bring more awareness to the currently available guidelines on PPI use, discuss clinical indications for PPIs and the evidence behind the reported side-effects. We hope that increased awareness of proper PPI use will make the initiation or continuation of therapy a well informed and an evidence-based decision between patient and physician. We also hope that discussing evidence behind the reported side-effect profile will help clarify the growing concerns over PPI therapy.
质子泵抑制剂（PPI）疗法引入临床实践彻底改变了酸相关疾病的治疗方法。随着其在临床上的成功，PPI 疗法得到了广泛应用。随后，多项研究发现，质子泵抑制剂在初级保健和急诊环境中经常被过度开具，这可能归因于其似乎较低的副作用风险和医生启动治疗的门槛较低。然而，现在患者和医务人员都越来越关注质子泵抑制剂的副作用。我们希望提高对目前可用的质子泵抑制剂使用指南的认识，讨论质子泵抑制剂的临床适应证以及报告的副作用背后的证据。我们希望增加对质子泵抑制剂合理使用的认识，使患者和医生之间的治疗启动或持续成为一个明智的、基于证据的决策。我们还希望讨论报告的副作用背后的证据，以帮助澄清对质子泵抑制剂治疗的日益关注。
