Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Curr Gastroenterol Rep. 2023 Nov;25(11):289-298. doi: 10.1007/s11894-023-00893-6. Epub 2023 Sep 2.
This review presents and summarizes the existing studies on the treatment goals and options for pediatric eosinophilic esophagitis utilizing rigorous peer-reviewed literature.
In addition to traditional treatments, emerging biologic therapies continue to evolve the approach to treating pediatric eosinophilic esophagitis. Well defined treatment goals will aid the continued development of new therapies. Further, innovative assessment tools have changed how the clinician is able to assess the effectiveness of therapies with a trend toward less invasive options. The management of pediatric eosinophilic esophagitis continues to evolve with the advent of both novel treatment options and assessment tools. Treatment choices, with benefits and risks involved, should be presented to families upon diagnosis and tailored towards the individual patient and likelihood of adherence and success. Biologic therapy for EoE presents an exciting option for both first line therapy and escalation for those with severe or unresponsive disease.
本综述通过严格的同行评议文献，介绍并总结了目前针对小儿嗜酸性食管炎的治疗目标和选择的研究现状。
除了传统治疗方法，新兴的生物治疗方法也在不断发展，为治疗小儿嗜酸性食管炎提供新的选择。明确的治疗目标将有助于开发新疗法。此外，创新的评估工具改变了临床医生评估治疗效果的方式，倾向于采用创伤更小的方法。随着新型治疗方法和评估工具的出现，小儿嗜酸性食管炎的治疗也在不断发展。在诊断时应向患儿家庭介绍治疗选择及其潜在获益和风险，并根据个体患者的情况、治疗的依从性和成功率进行个体化治疗。对于 EoE，生物治疗是一种很有前景的治疗方法，可作为一线治疗或严重或难治性疾病的升级治疗选择。
