Sun Jun-Jie, Zhang Shi-Yu, Tian Jun-Jie, Jin Bai-Ye
Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311000, Zhejiang Province, China.
World J Clin Cases. 2022 Jul 6;10(19):6609-6616. doi: 10.12998/wjcc.v10.i19.6609.
Metastasis to the penis is an unusual event, and penile metastasis from rectal carcinoma (PMRC) is extremely rare and associated with a dismal prognosis. Thus far, approximately 80 cases have been reported.
Herein, we report the case of a 49-year-old man with PMRC. The patient presented to the urology clinic with a complaint of penile pain during urination. The patient underwent the Dixon operation for rectal carcinoma 2 mo before the presentation. During hospitalisation, abdominal computed tomography revealed a nodular lesion on the left penis. The postoperative pathological examination revealed a typical intestinal-type adenocarcinoma. Previous cases of PMRC were retrieved from PubMed to characterise the clinicopathological features and identify the prognostic factors of PMRC.
The analysis suggested that approximately 24 mo is the median time to metastasis occurrence and 150 d is the survival time after diagnosis. Furthermore, poor pathological differentiation, lymph node involvement of the primary RC, metastasis time < 6 mo, penile metastatic nodule diameter > 1 cm, and treatment abandonment are negative predictors of survival outcomes. Close follow-up, surgical resection, chemotherapy, and radiotherapy may potentially improve the prognosis of patients.
阴茎转移是一种罕见情况，直肠癌阴茎转移（PMRC）极为罕见且预后不良。迄今为止，已报道约80例病例。
在此，我们报告一例49岁的PMRC男性患者。该患者因排尿时阴茎疼痛就诊于泌尿外科门诊。患者在就诊前2个月因直肠癌接受了狄克逊手术。住院期间，腹部计算机断层扫描显示左侧阴茎有一个结节性病变。术后病理检查显示为典型的肠型腺癌。从PubMed检索先前的PMRC病例，以描述其临床病理特征并确定PMRC的预后因素。
分析表明，转移发生的中位时间约为24个月，诊断后的生存时间为150天。此外，病理分化差、原发性直肠癌淋巴结受累、转移时间<6个月、阴茎转移结节直径>1 cm以及放弃治疗是生存结果的负性预测因素。密切随访、手术切除、化疗和放疗可能会改善患者的预后。
