阴茎癌患者手术后的预后因素。
Prognostic factors in patients with penile cancer after surgical management.
机构信息
Department of Urology, Central Hospital of Yongzhou, Yongzhou, 425006, China.
Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
出版信息
World J Urol. 2018 Mar;36(3):435-440. doi: 10.1007/s00345-017-2167-5. Epub 2018 Jan 3.
PURPOSE
To examine the possible prognostic factors in patients with penile cancer after surgical management and to identify the independent predictive factors of the prognosis.
MATERIALS AND METHODS
Clinical data of 135 patients with penile cancer who underwent surgical management in two medical centers were collected. Follow-up data were available for 103 patients. Possible prognostic factors including patient's age; smoking or not; course of disease; phimosis or not; type of surgery; tumor stage; nodal stage; tumor grade and pathological lymph nodes metastasis were retrospectively analyzed by univariate and multivariate analyses with Cox regression.
RESULTS
Five-year cancer-specific survival (CSS) and 1-year CSS were 88.5 and 98.1%, respectively. Univariate Cox analysis revealed that nodal stage and pathological lymph nodes metastasis were significant prognostic factors. Multivariate Cox analysis revealed pathological lymph nodes metastasis was the independent predictive factor of the prognosis.
CONCLUSION
Pathological lymph nodes metastasis is the independent predictive factor worsening the prognosis in patients with penile cancer.
目的
探讨阴茎癌患者手术后的可能预后因素，并确定独立的预后预测因素。
材料与方法
收集了两个医学中心 135 例接受手术治疗的阴茎癌患者的临床资料。103 例患者有随访数据。通过单因素和多因素 COX 回归分析，回顾性分析了可能的预后因素，包括患者年龄、吸烟情况、病程、包茎情况、手术类型、肿瘤分期、淋巴结分期、肿瘤分级和病理淋巴结转移。
结果
5 年癌症特异性生存率（CSS）和 1 年 CSS 分别为 88.5%和 98.1%。单因素 COX 分析显示，淋巴结分期和病理淋巴结转移是显著的预后因素。多因素 COX 分析显示，病理淋巴结转移是预后的独立预测因素。
结论
病理淋巴结转移是阴茎癌患者预后不良的独立预测因素。
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