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用10%艾氟康唑溶液治疗硬皮病患者指甲甲癣：一例报告

Treatment of Fingernail Onychomycosis with Efinaconazole 10% Solution in a Patient with Scleroderma: A Case Report.

作者信息

Miller Rhiannon C, Lipner Shari R

机构信息

Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.

出版信息

Skin Appendage Disord. 2022 Jul;8(4):350-353. doi: 10.1159/000522407. Epub 2022 Mar 9.

DOI:10.1159/000522407
PMID:35979526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9274809/
Abstract

INTRODUCTION

Oral antifungals are typically preferred over topicals for moderate to severe onychomycosis due to efficacy and shorter treatment courses. However, systemics are contraindicated or cautioned in patients with liver dysfunction and with some autoimmune diseases, and in those taking interacting medications. Efinaconazole 10% solution is a topical antifungal therapy, but application for fingernail onychomycosis has not been adequately studied.

CASE PRESENTATION

We present a case of a 78-year-old female with scleroderma and moderate onychomycosis of the right 4th fingernail successfully treated with topical efinaconazole 10% solution.

CONCLUSION

We review the literature on contraindications to oral antifungals for onychomycosis, precautions with terbinafine in patients with some autoimmune diseases, and topical onychomycosis therapies. Topical efinaconazole may represent an effective alternative for patients with fingernail onychomycosis who have contraindications to oral medications.

摘要

引言

由于疗效和较短的疗程，口服抗真菌药物通常比局部用药更适合中重度甲癣。然而，肝功能不全患者、患有某些自身免疫性疾病的患者以及正在服用相互作用药物的患者禁用或慎用全身性药物。10%的艾氟康唑溶液是一种局部抗真菌疗法，但用于治疗手指甲甲癣的研究尚不充分。

病例报告

我们报告一例78岁女性患者，患有硬皮病，右手中指患有中度甲癣，使用10%的艾氟康唑溶液局部治疗成功。

结论

我们回顾了关于口服抗真菌药物治疗甲癣的禁忌证、特比萘芬在某些自身免疫性疾病患者中的注意事项以及局部甲癣治疗方法的文献。对于口服药物有禁忌证的手指甲甲癣患者，局部使用艾氟康唑可能是一种有效的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/9274809/e0f33910d76c/sad-0008-0350-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/9274809/67e5e25b5fcc/sad-0008-0350-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/9274809/d96d4428f725/sad-0008-0350-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/9274809/e0f33910d76c/sad-0008-0350-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/9274809/67e5e25b5fcc/sad-0008-0350-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/9274809/d96d4428f725/sad-0008-0350-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1126/9274809/e0f33910d76c/sad-0008-0350-g03.jpg

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Green nail syndrome: Analysis of the association with onychomycosis.绿甲综合征：与甲癣相关性分析
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Onychomycosis: An Updated Review.甲癣：最新综述
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Retrospective Case Series on Risk Factors, Diagnosis and Treatment of Pseudomonas aeruginosa Nail Infections.回顾性病例系列研究：铜绿假单胞菌甲真菌感染的危险因素、诊断与治疗。
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Topical efinaconazole: A promising therapeutic medication for tinea unguium.局部用依氟康唑：甲癣治疗的有前途的治疗药物。
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Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.5%他唑巴坦 topical 溶液治疗甲真菌病的疗效和安全性：两项随机 III 期研究结果。
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Subacute cutaneous lupus erythematosus induced by terbinafine: case report and review of literature.特比萘芬诱发的亚急性皮肤型红斑狼疮：病例报告及文献复习
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