Frech Tracy M, Mar Diane
Department of Internal Medicine, Division of Rheumatology, University of Utah, Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, USA.
Department of Internal Medicine, University of Colorado, Denver, 12631 East 17th Avenue, Aurora, CO 80045, USA.
Rheum Dis Clin North Am. 2018 Feb;44(1):15-28. doi: 10.1016/j.rdc.2017.09.002.
Although classification criteria for systemic sclerosis (SSc) do not incorporate gastrointestinal tract (GIT) manifestations often present in this disease, the GIT is the most common internal organ involved. Pathophysiology of GIT involvement is thought to be similar to other organs in SSc with fibroproliferative vascular lesions of small arteries and arterioles, increased production of profibrotic growth factors, and alterations of innate, humoral, and cellular immunity. These processes result in neuropathy progressing to myopathy with eventual fibrosis. Proper diagnostics and therapeutics for SSc-GIT involvement require the treating physician to have an understanding of an integrated approach and potential medication adverse effects.
尽管系统性硬化症（SSc）的分类标准未纳入该疾病中常见的胃肠道（GIT）表现，但胃肠道却是受累最常见的内脏器官。胃肠道受累的病理生理学被认为与系统性硬化症的其他器官相似，存在小动脉和小动脉的纤维增生性血管病变、促纤维化生长因子产生增加以及先天性、体液性和细胞免疫的改变。这些过程导致神经病变发展为肌病并最终形成纤维化。对于系统性硬化症胃肠道受累的正确诊断和治疗需要主治医生了解综合治疗方法以及潜在的药物不良反应。
