Ghosh Pritam, Ruan Guilin, Fridman Natalia, Maayan Galia
Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Technion City, Haifa 3200008, Israel.
Chem Commun (Camb). 2022 Sep 1;58(71):9922-9925. doi: 10.1039/d2cc02717h.
Incorporating a chiral non-coordinating substitution at the N-terminal end within peptoids facilitates regio-selective amide bond hydrolysis mediated by a transition metal ion and/or an acidic buffer as evident by X-ray crystallographic analysis, supported by ESI-MS. This opens up a new direction for peptidomimetic compounds towards future application in chemistry, biology and medicine.
在类肽的N端引入手性非配位取代基，有利于过渡金属离子和/或酸性缓冲液介导的区域选择性酰胺键水解，X射线晶体学分析证明了这一点，并得到电喷雾电离质谱（ESI-MS）的支持。这为拟肽化合物在化学、生物学和医学领域的未来应用开辟了新方向。
