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Int J Syst Evol Microbiol. 2018 Jul;68(7):2386-2392. doi: 10.1099/ijsem.0.002809. Epub 2018 May 24.
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Metformin: a review of its potential indications.二甲双胍：对其潜在适应证的综述
Drug Des Devel Ther. 2017 Aug 22;11:2421-2429. doi: 10.2147/DDDT.S141675. eCollection 2017.
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两种可将二甲双胍作为唯一氮源的假单胞菌分离株的基因组序列

Genome Sequences of Two Pseudomonas Isolates That Can Use Metformin as the Sole Nitrogen Source.

作者信息

Hillmann Katie B, Niehaus Thomas D

机构信息

Department of Plant and Microbial Biology, University of Minnesota, St. Paul, Minnesota, USA.

出版信息

Microbiol Resour Announc. 2022 Sep 15;11(9):e0063922. doi: 10.1128/mra.00639-22. Epub 2022 Aug 18.

DOI:10.1128/mra.00639-22
PMID:35980179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9476953/
Abstract

Metformin is a major water pollutant globally. We report the complete genome sequences of two pseudomonads, Pseudomonas sp. strain KHPS1 and Pseudomonas hydrolytica strain KHPS2, isolated from wastewater treatment plant sludge, which can grow on metformin as the nitrogen source. Both isolates contained ~80-kb plasmids that may contain metformin breakdown genes.

摘要

二甲双胍是全球主要的水污染物。我们报告了从污水处理厂污泥中分离出的两种假单胞菌，即假单胞菌属菌株KHPS1和水解假单胞菌菌株KHPS2的完整基因组序列，它们可以利用二甲双胍作为氮源生长。这两种分离株都含有约80 kb的质粒，其中可能包含二甲双胍分解基因。