Morris J C, Rubin E H, Morris E J, Mandel S A
J Gerontol. 1987 Jul;42(4):412-7. doi: 10.1093/geronj/42.4.412.
In a longitudinal study of senile dementia and healthy aging, the occurrence of serious falls was examined in participants with senile dementia of the Alzheimer's type (SDAT) (n = 44) and in cognitively healthy elderly control participants (n = 56) over a 4-year period. Falls occurred in 36% of SDAT individuals versus 11% of controls. The higher frequency of falls in demented participants was not explained by greater neurologic deficit nor by increased drug use compared with controls. However, males with SDAT who reported falls, had higher mean blood pressures and were more likely to be medicated than males with SDAT who did not fall. These differences were not observed in women. Falls in SDAT participants were associated with an increased rate of institutionalization. SDAT is an important risk factor for serious falls, and falls are associated with loss of independence in demented patients.
在一项关于老年痴呆症与健康衰老的纵向研究中,对44名阿尔茨海默型老年痴呆症(SDAT)患者和56名认知功能正常的老年对照参与者进行了为期4年的严重跌倒发生率检查。SDAT患者中有36%发生了跌倒,而对照组为11%。与对照组相比,痴呆患者跌倒频率较高并非由更严重的神经功能缺损或药物使用增加所致。然而,报告有跌倒的SDAT男性患者平均血压较高,且比未跌倒的SDAT男性患者更有可能正在接受药物治疗。女性中未观察到这些差异。SDAT患者跌倒与入住养老院的比例增加有关。SDAT是严重跌倒的一个重要危险因素,跌倒与痴呆患者失去独立生活能力有关。