Chéour Sarah, Chéour Chouaieb, Gendreau Tommy, Bouazizi Majdi, Singh Kumar Purnendu, Saeidi Ayoub, Tao Dan, Supriya Rashmi, Bragazzi Nicola Luigi, Baker Julien S, Chéour Foued
High Institute of Sport and Physical Education of Ksar-Saïd, Manouba, Tunisia.
Physical Education and Sports Pavilion, Laval University, Quebec City, QC, Canada.
Front Aging Neurosci. 2023 Jul 19;15:1216052. doi: 10.3389/fnagi.2023.1216052. eCollection 2023.
The purpose of this study was to compare the effects of music therapy (MT) and/or physical rehabilitation (PR) on cognitive and motor function in elderly Tunisian male and female patients with mild Alzheimer's disease (AD). Male patients (: 16; age: 74.19 ± 4.27 years; weight: 76.71 ± 5.22 kg) and female patients (: 12; age: 71.46 ± 3.36 years; weight: 67.47 ± 4.31 kg) with mild AD were randomly assigned into 4 groups including control group (Co), PR group participated in physical rehabilitation, MT group received music therapy and MT + PR received both music therapy and physical rehabilitation. Participants were required to engage in the study for four months with three 60-min sessions per week. We found all scores of cognitive (MMSE, ADAS-Cog Total and the ADAS-Cog Memory subscale) and motor functions (step length, walking speed, 6MVT and BBS score) evaluated were the greatest in MT + PR compared to the other groups. Our study also demonstrated that MT has a greater effect on cognitive function, while PR has a more pronounced effect on motor function. Changes in MMSE scores were significantly positively correlated in the PR, MT and MT + PR groups with improvements in all motor functions including step length ( = 0.77), walking speed ( = 0.73), 6MVT ( = 0.75) and BBS scores ( = 0.78) in AD patients. In conclusion, the combination of MT and PR seems to be an appropriate intervention approach that needs consideration as a treatment strategy for elderly male and female patients with mild AD.
本研究的目的是比较音乐疗法（MT）和/或物理康复（PR）对患有轻度阿尔茨海默病（AD）的突尼斯老年男性和女性患者认知和运动功能的影响。患有轻度AD的男性患者（n = 16；年龄：74.19±4.27岁；体重：76.71±5.22 kg）和女性患者（n = 12；年龄：71.46±3.36岁；体重：67.47±4.31 kg）被随机分为4组，包括对照组（Co）、参与物理康复的PR组、接受音乐疗法的MT组以及接受音乐疗法和物理康复的MT + PR组。参与者需要参与该研究四个月，每周进行三次60分钟的疗程。我们发现，与其他组相比，MT + PR组中评估的所有认知（MMSE、ADAS-Cog总分和ADAS-Cog记忆子量表）和运动功能（步长、步行速度、6分钟步行试验和Berg平衡量表评分）得分最高。我们的研究还表明，MT对认知功能有更大影响，而PR对运动功能有更显著影响。PR组、MT组和MT + PR组中MMSE评分的变化与AD患者所有运动功能的改善显著正相关，包括步长（r = 0.77）、步行速度（r = 0.73）、6分钟步行试验（r = 0.75）和Berg平衡量表评分（r = 0.78）。总之，MT和PR的联合似乎是一种合适的干预方法，作为患有轻度AD的老年男性和女性患者的治疗策略值得考虑。
