Nephrology Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Blood Purification, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
PLoS One. 2022 Aug 18;17(8):e0272237. doi: 10.1371/journal.pone.0272237. eCollection 2022.
By analyzing the pathological characteristics and clinical data of renal biopsy in our hospital in the past 20 years, to further understand the epidemic characteristics and pathological changes of primary glomerular disease, and to provide regional data for the big data of kidney disease in my country.
A retrospective analysis of 9448 patients with primary glomerular disease who were hospitalized in our hospital from January 1, 2000 to December 31, 2019, aged 18 years or older, and undergoing renal biopsy. Divided every 5 years into a group, a total of 4 groups (first group 2000.1.1-2004.12.31, second groups 2005.1.1-2009.12.31; third groups 2010.1.1-2014.12.31, fourth groups 2015.1.1-2019.12.31).
① There were more males than females, and male: female vs 1.53:1. The proportion of men in the past five years has increased compared with the previous 15 years. ② Mostly middle-aged, with a median age of 41.39 years old. The age is increasing over time. There are differences between the four groups, P <0.001; ③ The most common clinical manifestations are nephrotic syndrome, followed by chronic glomerulonephritis. Occult glomerulonephritis, the proportion of patients with nephrotic syndrome increases over time, first to fourth group (40.08%< 42.64% < 47.08%< 53.69%); ④ The most common pathology type from 2000 to 2009 was mesangial proliferative glomerulonephritis. IgA nephropathy was the most common type from 2010 to 2014, but the proportion of membranous nephropathy increased year by year, and it became the most common pathological type from 2015 to 2019; ⑤ The clinical and pathological manifestations of different genders are different, but there is no statistical difference.
In the past 20 years, the primary glomerular disease is mainly middle-aged. There are more men than women. The most common type of clinical manifestation is nephrotic syndrome. The pathological type is mesangial proliferative glomerulonephritis. Over time, the average age is increasing, and the proportion of patients with renal syndrome is increasing. IgA nephropathy is the most common pathological type from 2010 to 2014, and membranous nephropathy has become the main pathological type in the past 5 years.
通过分析我院近 20 年来的肾活检病理特点和临床资料，进一步了解原发性肾小球疾病的流行特点和病理变化，为我国肾脏病大数据提供区域性数据。
回顾性分析 2000 年 1 月 1 日至 2019 年 12 月 31 日在我院住院，年龄≥18 岁，并行肾活检的原发性肾小球疾病患者 9448 例。每 5 年为一组，共分为 4 组（第 1 组：2000.1.1-2004.12.31；第 2 组：2005.1.1-2009.12.31；第 3 组：2010.1.1-2014.12.31；第 4 组：2015.1.1-2019.12.31）。
①患者中男性多于女性，男∶女为 1.53∶1，近 5 年男性比例较前 15 年增加。②以中壮年为主，中位年龄 41.39 岁，随时间推移年龄逐渐增加，4 组间比较差异有统计学意义（P<0.001）；③临床表现以肾病综合征最多见，其次为慢性肾小球肾炎，隐匿性肾小球肾炎，随时间推移，患者中肾病综合征比例逐渐增加，第 1 至第 4 组分别为（40.08%<42.64%<47.08%<53.69%）；④2000 至 2009 年最常见的病理类型为系膜增生性肾小球肾炎，2010 至 2014 年最常见的类型为 IgA 肾病，但膜性肾病比例逐年增加，2015 至 2019 年成为最常见的病理类型；⑤不同性别患者的临床表现和病理类型有差异，但差异无统计学意义。
近 20 年来我院原发性肾小球疾病以中壮年为主，男性多于女性，临床表现以肾病综合征最多见，病理类型以系膜增生性肾小球肾炎为主，随时间推移，平均年龄逐渐增加，肾病综合征患者比例逐渐增加，2010 年至 2014 年最常见的病理类型为 IgA 肾病，膜性肾病近 5 年成为主要的病理类型。
