Key Laboratory of Microbial Drugs Innovation and Transformation of Yan'an, School of Basic Medicine, Yan'an University, Yan'an 716000, Shaanxi, China; Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources,Yan'an University, NO.580 Shengdi Road, Baota District, Yan'an 716000, Shaanxi, China.
J Infect Public Health. 2022 Sep;15(9):986-1000. doi: 10.1016/j.jiph.2022.08.004. Epub 2022 Aug 10.
With the widespread use of immunosuppressive agents and the increase in patients with severe infections, the incidence of fungal infections worldwide has increased year by year. The fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus cause a total of more than 1 million deaths each year. Long-term use of antifungal drugs can easily lead to fungal resistance, and the prevalence of drug-resistant fungi is a major global health challenge. In order to effectively control global fungal infections, there is an urgent need for new drugs that can exert effective antifungal activity and overcome drug resistance. We must promote the discovery of new antifungal targets and drugs, and find effective ways to control drug-resistant fungi through different ways, so as to reduce the threat of drug-resistant fungi to human life, health and safety. In the past few years, certain progress has been made in the research and development of antifungal drugs. In addition to summarizing some of the antifungal drugs currently approved by the FDA, this review also focuses on potential antifungal drugs, the repositioned drugs, and drugs that can treat drug-resistant bacteria and fungal infections, and provide new ideas for the development of antifungal drugs in the future.
随着免疫抑制剂的广泛使用和严重感染患者的增加，全球真菌感染的发病率逐年上升。真菌病原体白色念珠菌、新生隐球菌和烟曲霉每年总共导致超过 100 万人死亡。长期使用抗真菌药物容易导致真菌耐药，耐药真菌的流行是一个主要的全球健康挑战。为了有效控制全球真菌感染，迫切需要能够发挥有效抗真菌活性并克服耐药性的新药。我们必须推动新的抗真菌靶标和药物的发现，并通过不同途径寻找有效控制耐药真菌的方法，从而降低耐药真菌对人类生命、健康和安全的威胁。在过去几年中，抗真菌药物的研究和开发取得了一定的进展。除了总结目前 FDA 批准的一些抗真菌药物外，本综述还重点介绍了一些有潜力的抗真菌药物、再定位药物以及能够治疗耐药细菌和真菌感染的药物，为未来抗真菌药物的开发提供了新的思路。
