Chen Ge, Wu Yinglin, Qian Zhengmin Min, Wang Xiaojie, Howard Steven W, McMillin Stephen Edward, Lin Hualiang, Ruan Zengliang, Zhang Zilong
Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, PR China.
Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, St. Louis, MO 63104, United States of America.
Sci Total Environ. 2022 Dec 10;851(Pt 1):157979. doi: 10.1016/j.scitotenv.2022.157979. Epub 2022 Aug 15.
Currently, there is no evidence of fine particulate matter pollution (PM) altering the relationship between physical activity (PA) and the risk of conjunctivitis.
Based on the UK Biobank study, we included 308,507 participants aged 40-69 years at baseline (2006 to 2010) and prospectively followed up for conjunctivitis diagnosis till 2020. Annual concentrations of PM in 2010 were estimated for each participant using Land Use Regression models. PA levels during work and leisure time were reported via the International Physical Activity Questionnaire at baseline. We used Cox proportional hazards models to examine the associations of PM and PA with incident conjunctivitis, as well as their interaction at both multiplicative and additive scales.
During the 11.6 years of follow up, we identified 4002 incident conjunctivitis cases. High-PA (≥3000 metabolic equivalent of task [MET]-mins/week) was associated with lower risk of conjunctivitis (hazard ratio [HR]: 0.79, 95% confidence interval [CI]: 0.73-0.86) compared to low-PA (0 to <600 MET-mins/week), while every 1 μg/m increment in PM was associated with a 16% higher risk of conjunctivitis (HR = 1.16, 95% CI: 1.09-1.23). We did not observe statistically significant interactions between PM and PA on their associations with conjunctivitis.
Habitual PA and PM exposure were oppositely related to incident conjunctivitis. The benefits of PA remain in people irrespective of exposure to air pollution.
目前，尚无证据表明细颗粒物污染（PM）会改变身体活动（PA）与结膜炎风险之间的关系。
基于英国生物银行研究，我们纳入了308507名基线年龄在40至69岁之间（2006年至2010年）的参与者，并对其进行前瞻性随访直至2020年以诊断结膜炎。使用土地利用回归模型估算了每位参与者2010年的年度PM浓度。在基线时通过国际身体活动问卷报告工作和休闲时间的PA水平。我们使用Cox比例风险模型来研究PM和PA与新发结膜炎的关联，以及它们在乘法和加法尺度上的相互作用。
在11.6年的随访期间，我们确定了4002例新发结膜炎病例。与低PA（0至<600代谢当量任务[MET]-分钟/周）相比，高PA（≥3000 MET-分钟/周）与较低的结膜炎风险相关（风险比[HR]：0.79，95%置信区间[CI]：0.73-0.86），而PM每增加1μg/m³与结膜炎风险高16%相关（HR = 1.16，95% CI：1.09-1.23）。我们未观察到PM和PA在与结膜炎关联方面存在统计学上的显著相互作用。
习惯性PA和PM暴露与新发结膜炎呈相反关系。无论是否暴露于空气污染，PA的益处对人们依然存在。
