Wu Z Y, Gao W J, Cao J, Lyu C Q, Yu S F, Wang T, Huang D J Y, Sun C X, Liao Y J, Pang Z C, Pang M, Yu H, Wang X P, Wu Z, Dong F, Wu G J, Jiang X J, Wang Y, Liu J, Deng L, Lu L M, Li Liming
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.
Qingdao Center for Disease Control and Prevention, Qingdao 266033, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2022 Aug 10;43(8):1241-1248. doi: 10.3760/cma.j.cn112338-20211210-00964.
To describe the distribution characteristics of tea consumption in adult twins recruited in the Chinese National Twin Registry (CNTR) and provide clues to genetic and environmental influences on tea consumption. Enrolled in CNTR during 2010-2018, 25 264 twin pairs aged 18 years and above were included in subsequent analysis. Random effect models were used to estimate tea consumption in the population and regional distribution characteristics. The concordance rate of the behavior and difference in consumption volume of tea within pairs were also described. The mean age of all subjects was (35.38±12.45) years old. The weekly tea consumers accounted for 17.0%, with an average tea consumption of (3.36±2.44) cups per day. The proportion of weekly tea consumers was higher among males, 50-59 years old, southern, urban, educated, and the first-born in the twin pair (<0.05), and lower among unmarried individuals (<0.001). Within-pair analysis showed that the concordance rate of tea consumption of monozygotic (MZ) twins was higher than that of dizygotic (DZ) twins and the overall heritability of tea consumption was 13.45% (11.38%-15.51%). Stratified by the characteristics mentioned above, only in males, the concordance rate of MZ showed a tendency to be greater than that of DZ (all <0.05). The differences in consumption volume of tea within twin pairs were minor in MZ among males (<0.05), while the differences were not significant in female twins. There were discrepancies in the distribution of tea consumption among twins of different demographic and regional characteristics. Tea consumption was mainly influenced by environmental factors and slightly influenced by genetic factors. The size of genetic factors varied with gender, age, and region, and gender was a potential modified factor.
描述中国国家双胞胎登记处(CNTR)招募的成年双胞胎中茶叶消费的分布特征,并为茶叶消费的遗传和环境影响提供线索。在2010 - 2018年期间登记加入CNTR的25264对18岁及以上的双胞胎被纳入后续分析。采用随机效应模型估计人群中的茶叶消费量和区域分布特征。还描述了双胞胎对内茶叶消费行为的一致性率和消费量差异。所有受试者的平均年龄为(35.38±12.45)岁。每周饮茶者占17.0%,平均每天饮茶量为(3.36±2.44)杯。每周饮茶者的比例在男性、50 - 59岁、南方、城市、受过教育以及双胞胎中的头胎中较高(<0.05),而在未婚个体中较低(<0.001)。双胞胎对内分析表明,同卵双胞胎(MZ)的茶叶消费一致性率高于异卵双胞胎(DZ),茶叶消费的总体遗传度为13.45%(11.38% - 15.51%)。按上述特征分层后,仅在男性中,MZ的一致性率有大于DZ的趋势(均<0.05)。男性MZ双胞胎对内的茶叶消费量差异较小(<0.05),而女性双胞胎中差异不显著。不同人口统计学和区域特征的双胞胎在茶叶消费分布上存在差异。茶叶消费主要受环境因素影响,受遗传因素影响较小。遗传因素的大小随性别、年龄和地区而变化,性别是一个潜在的修饰因素。