Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Faculty of Medicine, Bangkokthonburi University, Bangkok, 10170, Thailand.
Sci Rep. 2022 Aug 18;12(1):14056. doi: 10.1038/s41598-022-18484-2.
This study aimed to evaluate the effect of a high protein diet comprising breast meat from commercial broiler (BR), Thai native (PD), and commercial broiler × Thai native crossbred (KKU-ONE) chicken on serum uric acid, biochemical parameters, and antioxidant activities in rats. Male Sprague-Dawley rats were divided into four groups. The control group received a standard chow diet, and the other three groups were fed a high protein diet (70% standard diet + 30% BR, PD, or KKU-ONE chicken breast) for five weeks. The PD- and KKU-ONE-fed rats had lower plasma total cholesterol and triglyceride levels than the control rats. A decrease in HDL-c was also observed in rats fed a diet containing BR. Liver weight, liver enzyme, plasma ALP, xanthine oxidase activity, serum uric acid, creatinine, superoxide production, and plasma malondialdehyde levels increased in BR-fed rats. The findings of this study might provide evidence to support the use of Thai native and Thai native crossbred chicken breast meat as functional foods.
本研究旨在评估由商业肉鸡(BR)、泰国本土鸡(PD)和商业肉鸡×泰国本土鸡杂交鸡(KKU-ONE)胸脯肉组成的高蛋白饮食对大鼠血清尿酸、生化参数和抗氧化活性的影响。雄性 Sprague-Dawley 大鼠被分为四组。对照组接受标准饲料,其余三组则接受高蛋白饮食(70%标准饮食+30%BR、PD 或 KKU-ONE 鸡胸肉)喂养五周。与对照组大鼠相比,PD 和 KKU-ONE 喂养的大鼠的血浆总胆固醇和甘油三酯水平较低。BR 喂养的大鼠的高密度脂蛋白胆固醇(HDL-c)也有所下降。BR 喂养的大鼠的肝重、肝酶、血浆碱性磷酸酶(ALP)、黄嘌呤氧化酶活性、血清尿酸、肌酐、超氧自由基生成和血浆丙二醛水平增加。本研究的结果可能为使用泰国本土和泰国本土杂交鸡胸脯肉作为功能性食品提供证据支持。