人类小脑结构和功能发育的多方面梯度。
A multifaceted gradient in human cerebellum of structural and functional development.
机构信息
Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China.
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
出版信息
Nat Neurosci. 2022 Sep;25(9):1129-1133. doi: 10.1038/s41593-022-01136-z. Epub 2022 Aug 18.
The organization of the basic tissue and functional properties of the cerebellum across development is unknown. Combining several large datasets, we demonstrate in the human cerebellum a static tissue gradient in adults that mirrors a similar growth-rate gradient across development. Quantitative tissue metrics corroborate unique densities of certain lipids and proteins among lobules, and cerebellar structural development closely follows cerebellar functional properties through childhood.
小脑在发育过程中的基本组织和功能特性的组织方式尚不清楚。我们结合了几个大型数据集，在人类小脑内发现了一个成人的静态组织梯度，该梯度反映了发育过程中类似的生长速度梯度。定量组织指标证实了某些脂质和蛋白质在小脑回之间具有独特的密度，并且小脑的结构发育在整个儿童期都与小脑的功能特性密切相关。
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