Division of Virology, Institute of Tropical Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Reprod Sci. 2023 Feb;30(2):722-727. doi: 10.1007/s43032-022-01067-x. Epub 2022 Aug 18.
The microbial composition of the human vagina differs from that of all other mammals, likely as a consequence of the unique composition of vaginal constituents that promote the selective maintenance and proliferation of distinct bacterial species. Similarly, variations between individual healthy women in genetic, environmental, and medical variables also modify the vaginal lumen composition. The direction and magnitude of immune reactions to microorganisms present in the vagina, responses to stress and non-infectious stimuli, coupled with medical and pregnancy history and environmental exposures, can greatly differ between women. Adaptations to both internal and external pressures will determine the ability of select resident vaginal bacteria to numerically dominate and, therefore, the definition of a "normal" vaginal microbiota will substantially differ between individual healthy women.
人类阴道的微生物组成与所有其他哺乳动物不同，这可能是由于阴道成分的独特组成促进了不同细菌物种的选择性维持和增殖。同样，个体健康女性在遗传、环境和医疗变量方面的差异也会改变阴道腔的组成。对阴道内存在的微生物的免疫反应的方向和程度、对压力和非传染性刺激的反应，加上医疗和怀孕史以及环境暴露，在女性之间可能有很大差异。对内部和外部压力的适应将决定选择的常驻阴道细菌的数量优势，因此，“正常”阴道微生物组在个体健康女性之间将有很大差异。
