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莫旺综合征表现为自身免疫性副肿瘤性脑炎,与胸腺瘤相关,并通过F 18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描检测到抗电压门控钾通道(富含亮氨酸,胶质瘤失活1)抗体。

Morvan Syndrome Manifesting as Autoimmune Paraneoplastic Encephalitis Associated with Thymoma and Antivoltage Gated Potassium Channel (Leucine Rich, Glioma Inactivated 1) Antibody Detected using F 18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

作者信息

Kamaleshwaran Koramadai Karuppusamy, Senthilkumar Elumalai, Ramkumar Elumalai, Ruth Rajasekaran

机构信息

Department of Nuclear Medicine, PET/CT and Radionuclide Therapy, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.

Department of Neurology, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.

出版信息

Indian J Nucl Med. 2022 Apr-Jun;37(2):166-168. doi: 10.4103/ijnm.ijnm_155_21. Epub 2022 Jul 8.

DOI:10.4103/ijnm.ijnm_155_21
PMID:35982802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9380793/
Abstract

Morvan's syndrome (MoS) is a rare, complex neurological disorder characterized by neuromyotonia, neuropsychiatric features, dysautonomia, and neuropathic pain. The majority of MoS cases have a paraneoplastic etiology, most commonly thymoma, usually occurring before the diagnosis of the underlying tumor and showing improvement following surgery. We present a case of 60-year-old patient presenting with suspicious of MoS and autoimmune encephalitis (AE), F-18 fluorodeoxyglucose positron emission tomography/computed tomography as single imaging modality detected and confirmed both AE and thymoma.

摘要

莫旺综合征(MoS)是一种罕见的复杂性神经疾病,其特征为神经肌强直、神经精神症状、自主神经功能障碍和神经性疼痛。大多数莫旺综合征病例有副肿瘤病因,最常见的是胸腺瘤,通常在潜在肿瘤诊断之前出现,并在手术后有所改善。我们报告一例60岁患者,疑似患有莫旺综合征和自身免疫性脑炎(AE),氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描作为单一成像方式检测并确诊了自身免疫性脑炎和胸腺瘤。

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1
Morvan Syndrome Manifesting as Autoimmune Paraneoplastic Encephalitis Associated with Thymoma and Antivoltage Gated Potassium Channel (Leucine Rich, Glioma Inactivated 1) Antibody Detected using F 18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.莫旺综合征表现为自身免疫性副肿瘤性脑炎,与胸腺瘤相关,并通过F 18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描检测到抗电压门控钾通道(富含亮氨酸,胶质瘤失活1)抗体。
Indian J Nucl Med. 2022 Apr-Jun;37(2):166-168. doi: 10.4103/ijnm.ijnm_155_21. Epub 2022 Jul 8.
2
Paraneoplastic Morvan's syndrome following surgical treatment of recurrent thymoma: A case report.复发性胸腺瘤手术治疗后伴发的副肿瘤性莫旺综合征:一例报告
Oncol Lett. 2016 Oct;12(4):2716-2719. doi: 10.3892/ol.2016.4922. Epub 2016 Jul 29.
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Case report: Complex paraneoplastic syndromes in thymoma with nephrotic syndrome, cutaneous amyloidosis, myasthenia gravis, and Morvan's syndrome.病例报告:胸腺瘤伴肾病综合征、皮肤淀粉样变、重症肌无力和莫旺综合征的复杂副肿瘤综合征。
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Isaacs' syndrome as the initial presentation of malignant thymoma and associated with double-positive voltage-gated potassium channel complex antibodies, a case report.以 Isaacs 综合征为首发表现的恶性胸腺瘤并伴有双阳性电压门控钾通道复合物抗体:一例报告
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Paraneoplastic disorders in thymoma patients.胸腺瘤患者的副肿瘤性疾病。
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本文引用的文献

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Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis.氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)显示的脑代谢异常是自身免疫性脑炎常见的早期表现。
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[Anti-VGKC antibody-associated limbic encephalitis/Morvan syndrome].[抗电压门控性钾通道抗体相关边缘叶脑炎/莫旺综合征]
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FDG-PET improves tumour detection in patients with paraneoplastic neurological syndromes.氟代脱氧葡萄糖正电子发射断层扫描(FDG-PET)可提高副肿瘤性神经综合征患者的肿瘤检测率。
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8
Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels.莫旺综合征:周围和中枢神经系统及心脏受累伴电压门控钾通道抗体。
Brain. 2001 Dec;124(Pt 12):2417-26. doi: 10.1093/brain/124.12.2417.