Bharadwaj V P, Sakai M, Ogawa K, Nishiura M
Int J Lepr Other Mycobact Dis. 1987 Jun;55(2):328-32.
The present study was undertaken to understand the lysosomal status and function in macrophages across the leprosy spectrum, including the reactional states. Acid phosphatase was used as the marker enzyme to demonstrate lysosomes at the electron microscopic level. It was observed that lysosomal morphology was well maintained in the macrophages of tuberculoid, borderline tuberculoid, and borderline tuberculoid leprosy in reaction, while they lost their cellular morphology and cell membrane integrity in lepromatous leprosy and lepromatous leprosy in reaction. The importance of these findings is discussed.
本研究旨在了解麻风病谱各型，包括反应状态下巨噬细胞的溶酶体状态和功能。酸性磷酸酶用作标记酶，在电子显微镜水平显示溶酶体。观察到结核样型、界线结核样型及界线结核样型麻风反应期巨噬细胞的溶酶体形态保持良好，而瘤型麻风及瘤型麻风反应期巨噬细胞失去细胞形态和细胞膜完整性。对这些发现的重要性进行了讨论。
