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动物模型中袖状胃切除术和次袖状胃切除术后的骨密度和脂肪指数

Bone Densitometry and Fat Index after Sleeve and Subsleeve Gastrectomy in Animal Model.

作者信息

Khazraei Hajar, Hosseini Seyed Vahid, Amini Masood, Amirzadeh Saeed, Dehghanian Amirreza, Sobhani Zahra, Kasraei Hengameh

机构信息

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Laparoscopic Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Adv Biomed Res. 2022 Jun 29;11:48. doi: 10.4103/abr.abr_124_20. eCollection 2022.

Abstract

BACKGROUND

Previous studies have reported that gastrectomy and fundectomy can induce osteopenia. Body fat index is a new index of obesity that shows central obesity and other risks of obesity. Sleeve gastrectomy (SG) is a bariatric surgery and a new technique introduced as subsleeve, which only resected fundus of the stomach. In this study, it has been shown the effect of subsleeve and SG on fat index and bone densitometry in an animal model.

MATERIALS AND METHODS

Rabbits were underlined SG, fundectomy (surgical removal of fundus), or sham-operated (controls without any resection), and after 12 weeks, fat index and bone densitometry were obtained.

RESULTS

Our study showed that there was no significant difference between SG and fundectomy groups in bone mass density and fat mass after surgery in comparison with presurgery condition. SG group were associated with lower fat index and bone density, and it showed significantly decrease in weight after 1.5 months.

CONCLUSION

Sub-SG did not show any significant effect on fat index and bone densitometry in comparison with SG. However, we found lower fat index in sleeve group of rabbits, but it was not statistically significant.

摘要

背景

先前的研究报告称,胃切除术和胃底切除术可导致骨质减少。体脂指数是一种新的肥胖指标,可显示中心性肥胖和其他肥胖风险。袖状胃切除术(SG)是一种减肥手术,也是一种作为次袖状手术引入的新技术,仅切除胃底。在本研究中,已在动物模型中显示了次袖状手术和袖状胃切除术对脂肪指数和骨密度测定的影响。

材料与方法

对兔子进行袖状胃切除术、胃底切除术(手术切除胃底)或假手术(未进行任何切除的对照组),12周后,测量脂肪指数和骨密度。

结果

我们的研究表明,与术前相比,袖状胃切除术组和胃底切除术组术后的骨密度和脂肪量没有显著差异。袖状胃切除术组的脂肪指数和骨密度较低,并且在1.5个月后体重显著下降。

结论

与袖状胃切除术相比,次袖状胃切除术对脂肪指数和骨密度测定没有显示出任何显著影响。然而,我们发现兔子袖状胃切除术组的脂肪指数较低,但差异无统计学意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5627/9379916/fee1c0bca123/ABR-11-48-g001.jpg

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