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自身免疫性 GFAP 星形胶质细胞病的血清生物标志物。

Serological biomarkers in autoimmune GFAP astrocytopathy.

机构信息

Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

出版信息

Front Immunol. 2022 Aug 2;13:957361. doi: 10.3389/fimmu.2022.957361. eCollection 2022.

DOI:10.3389/fimmu.2022.957361
PMID:35983033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9378990/
Abstract

Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a newly defined meningoencephalomyelitis. The pathogenesis of GFAP-A is not well understood. The present study measured the expression levels of 200 serological cytokines in GFAP-A patients, NMOSD patients and healthy controls (HCs). The correlations between serum cytokine levels and clinical information in GFAP-A patients were analyzed. A total of 147 serological proteins were differentially expressed in GFAP-A patients compared to HCs, and 33 of these proteins were not observed in NMOSD patients. Serum levels of EG-VEGF negatively correlated with GFAP antibody titers, MIP-3 alpha positively correlated with clinical severity in GFAP-A patients, and LIGHT positively correlated with WBC counts and protein levels in the CSF of GFAP-A patients. These results suggest that GFAP and AQP4 astrocytopathy share some common pathology related to TNF signaling. Serum MIP 3 alpha may be a biomarker to assess clinical severity and a potential target for therapy of autoimmune GFAP astrocytopathy.

摘要

自身免疫性神经胶质纤维酸性蛋白星形胶质细胞病 (GFAP-A) 是一种新定义的脑膜脑脊髓炎。GFAP-A 的发病机制尚不清楚。本研究测量了 GFAP-A 患者、NMOSD 患者和健康对照者 (HCs) 中 200 种血清细胞因子的表达水平。分析了 GFAP-A 患者血清细胞因子水平与临床资料之间的相关性。与 HCs 相比，GFAP-A 患者中有 147 种血清蛋白表达差异，其中 33 种蛋白在 NMOSD 患者中未观察到。血清 EG-VEGF 水平与 GFAP 抗体滴度呈负相关，MIP-3 alpha 与 GFAP-A 患者的临床严重程度呈正相关，而 LIGHT 与 GFAP-A 患者的白细胞计数和 CSF 蛋白水平呈正相关。这些结果表明，GFAP 和 AQP4 星形胶质细胞病与 TNF 信号转导有关的一些共同病理学。血清 MIP 3 alpha 可能是评估临床严重程度的生物标志物和自身免疫性 GFAP 星形胶质细胞病的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a31/9378990/1cb6cc3a6e1c/fimmu-13-957361-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a31/9378990/00e8dce2976f/fimmu-13-957361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a31/9378990/1cb6cc3a6e1c/fimmu-13-957361-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a31/9378990/4b3ab67e7543/fimmu-13-957361-g001.jpg
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