SeyedAlinaghi SeyedAhmad, Karimi Amirali, Mojdeganlou Hengameh, Pashaei Zahra, Mirzapour Pegah, Shamsabadi Ahmadreza, Barzegary Alireza, Afroughi Fatemeh, Dehghani Soheil, Janfaza Nazanin, Fakhfouri Amirata, Khodaei Sepideh, Mehraeen Esmaeil, Dadras Omid
Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
SAGE Open Med. 2022 Aug 11;10:20503121221115053. doi: 10.1177/20503121221115053. eCollection 2022.
Understanding the minimum infective dose is significant for risk assessment in the performance of suitable infection control strategies in healthcare centers. However, the literature lacks strong evidence regarding this value for severe acute respiratory syndrome coronavirus 2. Therefore, the aim of this study was to investigate the minimum infectious dose of coronavirus disease 2019.
We searched the databases of PubMed, Scopus, Web of Science, and Cochrane and retrieved all the relevant literature by 25 July 2021. The records were downloaded into the EndNote software and underwent title/abstract and full-text screenings. A summary of included studies was organized into tables for further analysis, interpretation, and drafting of the results.
Nineteen studies including the laboratory data on human and animal hosts were selected based on the eligibility criteria. All the literature reported on the infective dose, particularly in humans. The main methods for measurement of infection were through tissue culture infectious dose (TCID50) and counting plaque-forming units. The range of minimum infective was 1.26-7 × 10 PFU.
In this study, we have presented a range of minimum infective doses in humans and various animal species. Such numbers can possibly vary between the individuals based on numerous demographic, immunologic, or other factors.
了解最小感染剂量对于医疗中心实施适当感染控制策略中的风险评估具有重要意义。然而，关于严重急性呼吸综合征冠状病毒2的这一数值，文献中缺乏有力证据。因此，本研究的目的是调查2019冠状病毒病的最小感染剂量。
我们检索了PubMed、Scopus、Web of Science和Cochrane数据库，并检索了截至2021年7月25日的所有相关文献。记录被下载到EndNote软件中，并进行标题/摘要和全文筛选。将纳入研究的摘要整理成表格，以便进一步分析、解释和撰写结果。
根据纳入标准，选择了19项包括人类和动物宿主实验室数据的研究。所有文献均报告了感染剂量，尤其是在人类中的感染剂量。测量感染的主要方法是通过组织培养感染剂量（TCID50）和计数空斑形成单位。最小感染范围为1.26 - 7×10 PFU。
在本研究中，我们给出了人类和各种动物物种的最小感染剂量范围。基于众多人口统计学、免疫学或其他因素，这些数值在个体之间可能会有所不同。
