Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Healthcare Services Management, School of Medicine and Allied Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran.
Eur J Med Res. 2021 May 20;26(1):46. doi: 10.1186/s40001-021-00516-8.
While COVID-19 pandemic continues to spread worldwide, researchers have linked patterns of traits to poor disease outcomes. Risk factors for COVID-19 include asthma, elderly age, being pregnant, having any underlying diseases such as cardiovascular disease, diabetes, obesity, and experiencing lifelong systemic racism. Recently, connections to certain genes have also been found, although the susceptibility has not yet been established. We aimed to investigate the available evidence for the genetic susceptibility to COVID-19.
This study was a systematic review of current evidence to investigate the genetic susceptibility of COVID-19. By systematic search and utilizing the keywords in the online databases including Scopus, PubMed, Web of Science, and Science Direct, we retrieved all the related papers and reports published in English from December 2019 to September 2020.
According to the findings, COVID-19 uses the angiotensin-converting enzyme 2 (ACE2) receptor for cell entry. Previous studies have shown that people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) are at high risk of SARS-CoV-2 infection. Also, two studies have shown that males are more likely to become infected with SARS-CoV-2 than females. Besides, research has also shown that patients possessing HLA-B*15:03 genotype may become immune to the infection.
Combing through the genome, several genes related to immune system's response were related to the severity and susceptibility to the COVID-19. In conclusion, a correlation was found between the ACE2 levels and the susceptibility to SARS-CoV-2 infection.
随着 COVID-19 疫情在全球范围内继续蔓延，研究人员已经将某些特征模式与疾病不良预后联系起来。COVID-19 的风险因素包括哮喘、老年、怀孕、患有心血管疾病、糖尿病、肥胖症等任何潜在疾病，以及经历终身系统性种族主义。最近，也发现了与某些基因的关联，尽管易感性尚未确定。我们旨在调查 COVID-19 遗传易感性的现有证据。
本研究是对当前证据的系统综述，旨在调查 COVID-19 的遗传易感性。通过系统搜索并利用 Scopus、PubMed、Web of Science 和 Science Direct 等在线数据库中的关键词，我们检索了 2019 年 12 月至 2020 年 9 月期间以英文发表的所有相关论文和报告。
根据研究结果，COVID-19 使用血管紧张素转换酶 2（ACE2）受体进入细胞。先前的研究表明，具有 ACE2 多态性且具有 2 型跨膜丝氨酸蛋白酶（TMPRSS2）的人感染 SARS-CoV-2 的风险较高。此外，有两项研究表明，男性比女性更容易感染 SARS-CoV-2。此外，研究还表明，携带 HLA-B*15:03 基因型的患者可能对感染具有免疫力。
通过对基因组进行分析，与免疫系统反应相关的几个基因与 COVID-19 的严重程度和易感性有关。总之，发现 ACE2 水平与 SARS-CoV-2 感染易感性之间存在相关性。
