Lindhagen T, Bohe M, Ekelund G, Valentin L
Int J Colorectal Dis. 1986 Jan;1(1):25-7. doi: 10.1007/BF01648832.
Fertility and outcome of pregnancy were assessed in all 78 women below 40 years of age in a total, unselected series of patients with Crohn's disease, diagnosed during a 17-year period and consecutively treated with resectional surgery, in most cases at an early stage. The median follow-up time after the primary operation was 12.8 years. During the observation time there were 87 pregnancies in 44 patients. Neither the number of live births, nor the frequency of abortions differed from that expected in the general population. There was no still birth. The localization of the disease was not significant. In conclusion, there were no indications of any negative influence of surgical intervention.
在17年期间诊断出的一系列未经挑选的克罗恩病患者中,对所有78名40岁以下的女性进行了生育能力和妊娠结局评估,这些患者均接受了切除手术治疗,多数情况下处于疾病早期。初次手术后的中位随访时间为12.8年。在观察期内,44名患者共怀孕87次。活产数量和流产频率与普通人群预期的情况均无差异。没有死产情况。疾病的部位并无显著影响。总之,没有迹象表明手术干预会产生任何负面影响。