The Second Affiliated Hospital of Qiqihar Medical University, Clinical Pharmacy, China.
The Second Affiliated Hospital of Qiqihar Medical University, Department of Rehabilitation Medicine, China.
Comput Math Methods Med. 2022 Aug 9;2022:1481294. doi: 10.1155/2022/1481294. eCollection 2022.
To investigate the effect of injectable salvia polyphenolic acid on the improvement of limb movement and cognitive dysfunction in acute stroke patients.
The clinical data of 90 acute stroke patients were collected for retrospective study and divided into 45 cases each in the comparison group and the observation group according to the different treatment methods; using basic treatment + salvianolic acid, the comparison group implemented conventional alteplase and butalbital treatment, and the observation group used injectable salvianolic acid treatment, to observe and compare the clinical efficacy, changes in neurological deficits, cognitive function, and motor function scores before and after treatment in the two groups.
The NIHSS (National Institute of Health stroke scale) score, cerebral infarct volume, NSE (neuron-specific enolase), and S100 (A neurotrophic factor) levels were reduced after treatment compared with those before treatment in this group, and the NIHSS score, cerebral infarct volume, NSE, and S100 levels in the observation group were lower than those in the comparison group after treatment, and the difference was statistically significant ( < 0.05). Compared with the clinical efficacy of the comparison group and the observation group, the treatment effect of the observation group was better than that of the comparison group, and the difference was statistically significant ( < 0.05). After treatment, the cognitive function and motor function scores of both groups were significantly improved compared with those before treatment, and the degree of improvement of each score in the observation group was significantly better than that in the comparison group ( < 0.05). During the trial, two patients in the comparison group developed a generalized rash and withdrew from the experiment, and the rash subsided after anti-allergic treatment, and no significant adverse events were observed in the remaining participants. There was no statistically significant difference in liver and kidney function and cardiac enzyme test indexes between the two groups of patients at 14 days of treatment ( > 0.05).
Danshen polyphenolic acid for injection has definite clinical efficacy in the treatment of acute ischemic stroke, and it can effectively improve cognitive and motor functions and promote neurological recovery in patients with high safety.
研究注射用丹参多酚酸对改善急性脑卒中患者肢体运动和认知功能障碍的作用。
回顾性收集 90 例急性脑卒中患者的临床资料，根据不同治疗方法分为对照组和观察组各 45 例。对照组采用基础治疗+丹参多酚酸，对照组采用常规阿替普酶和布他比妥治疗，观察组采用注射用丹参多酚酸治疗，观察比较两组临床疗效、治疗前后神经功能缺损、认知功能、运动功能评分变化。
治疗后，两组 NIHSS（国立卫生研究院卒中量表）评分、脑梗死体积、NSE（神经元特异性烯醇化酶）和 S100（一种神经营养因子）水平均低于治疗前，观察组治疗后 NIHSS 评分、脑梗死体积、NSE 和 S100 水平均低于对照组，差异有统计学意义（ < 0.05）。与对照组和观察组的临床疗效相比，观察组的治疗效果优于对照组，差异有统计学意义（ < 0.05）。治疗后，两组认知功能和运动功能评分均明显高于治疗前，观察组各评分改善程度明显优于对照组（ < 0.05）。试验过程中，对照组有 2 例患者出现全身皮疹，退出试验，经抗过敏治疗后皮疹消退，其余患者未观察到明显不良反应。治疗 14 天时两组患者肝肾功能和心肌酶试验指标比较差异均无统计学意义（ > 0.05）。
丹参多酚酸注射液治疗急性缺血性脑卒中疗效确切，能有效改善患者的认知和运动功能，促进神经功能恢复，安全性高。
